Paracetamol Pediatric Elixir Pharmaceutics I Practical syllabus
Aim: Preparation and Evaluation of Paracetamol Pediatric Elixir / paracetamol elixir formulation
Glassware’s: Beaker, glass rod, glass funnel, glass bottle etc
Formula:
| Ingredients | Quantity given | Activity |
| Paracetamol | 24g | Antipyretic |
| Ethanol (90%) | 100 ml | Co solvent |
| Propylene glycol | 100 ml | Co solvent |
| Chloroform Spirit | 20 ml | Co solvent |
| Concentrated raspberry juice | 25 ml | Flavouring agent |
| Invert Syrup | 275 ml | Sweetening agent |
| Amaranth Solution | 2 ml | Colouring agent |
| Glycerine | q.s to 1000ml | Vehicle |
Procedure:
Time needed: 30 minutes
How to prepare Paracetamol Pediatric Elixir
- Measuring accurate quantity of cosolvents
Measure the accurate quantity of alcohol, propylene glycol and chloroform spirit
- Mix all cosolvents
Mix alcohol, propylene glycol and chloroform spirit
- Weigh and dissolve Paracetamol
Paracetamol should be weighed and dissolved in a mixture of alcohol, propylene glycol and chloroform spirit.
- Add other excipients
Add flavouring agents, Sweetening agents and colouring agents
- Make up the volume
Makeup the volume with purified water.
Category: Antipyretic.
Dose: 5 to 10 ml
Storage: Store in a cool, dry place away from light
Alcohol act as a cosolvent for paracetamol
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