Coca butter suppository Pharmaceutics I Practical
Aim:
Preparation and evaluation of Zinc Oxide suppository using Coca butter as a suppository base
Requirement:
Evaporating dish, glass rod, Suppository mould etc.
Formula:
| Ingredients | Quantity Given | Activity |
| Zinc Oxide | 120 mg | Astringent |
| Coca butter | q.s to | Suppository base |
Procedure:
The mould was lubricated with soft soap and kept in an inverted position for some time.
The quantity of base required was calculated by taking into consideration the displacement value of Zinc oxide and the capacity of mould. zinc oxide was passed through a sieve 60 mesh
Theobroma oil was melted in an evaporating dish on a warm water bath at a temperature not exceeding 36˚C. Zinc oxide was added to the molten cocoa butter and mixed.
The mixture was poured into the pre-lubricated mould and allowed to set on an ice bath for 5 minutes. the Excess was Scrap off. Suppositories were removed and packed in boxes lined by means of a separator
Precaution: Invert lubricated mould for some time before filling.
Category:
Astringent or Laxative
Container / Storage:
Store in a cool and dry place.
Labelling directions:
For rectal use only. Use 1 at night and 1 in the morning after defecation. Insert suppository as high as possible in the rectum.
Zinc Oxide suppositories are commonly used to treat various rectal conditions, including hemorrhoids and minor irritations. The purpose of using Zinc Oxide in suppositories is primarily for its soothing and protective properties on the rectal area.
Cocoa butter is an ideal choice for suppository bases due to its properties like excellent melting point, good compatibility with drugs, and minimal irritation to the rectal mucosa. Students might be asked about the specific advantages of using Cocoa butter in this formulation.
The preparation involves melting the Cocoa butter, adding Zinc Oxide to it, and homogenizing the mixture. This is followed by pouring the molten mass into suitable molds to obtain suppositories, which are then allowed to solidify.
The evaluation includes assessing various parameters such as weight variation, content uniformity, melting range, hardness, and possibly in vitro release studies. Students might be asked about the specific tests conducted and their significance in evaluating the quality of the suppositories.
Students might encounter challenges related to achieving uniform mixing of Zinc Oxide in the Cocoa butter base, controlling the melting temperature, or obtaining uniform suppositories with consistent properties. Understanding these challenges and their solutions is essential.
The properties like melting point, hardness, and uniformity influence the suppository’s stability, ease of administration, and drug release. Understanding these connections helps in designing effective and stable formulations.
Apart from rectal conditions, Zinc Oxide suppositories might have other therapeutic applications due to their anti-inflammatory and wound-healing properties. Exploring these broader applications can expand students’ understanding.
Students should be aware of safety protocols involving handling of hot substances, potential skin irritations from ingredients, and proper disposal of waste materials used in the experiment.
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