Coca butter suppository Pharmaceutics I Practical
Aim: Preparation and evaluation of Zinc Oxide suppository using Coca butter as a suppository base
Glassware’s: Evaporating dish, glass rod, Suppository mould etc.
Formula:
| Ingredients | Quantity Given | Activity |
| Zinc Oxide | 120 mg | Astringent |
| Coca butter | q.s to | Suppository base |
Procedure:
The mould was lubricated with soft soap and kept in an inverted position for some time.
The quantity of base required was calculated by taking into consideration the displacement value of Zinc oxide and the capacity of mould. zinc oxide was passed through a sieve 60 mesh
Theobroma oil was melted in an evaporating dish on a warm water bath at a temperature not exceeding 36˚C. Zinc oxide was added to the molten cocoa butter and mixed.
The mixture was poured into the pre-lubricated mould and allowed to set on an ice bath for 5 minutes. the Excess was Scrap off. Suppositories were removed and packed in boxes lined by means of a separator
Precaution: Invert lubricated mould for some time before filling.
Category: Astringent or Laxative
Container / Storage: Store in a cool and dry place.
Labelling directions: For rectal use only. Use 1 at night and 1 in the morning after defecation. Insert suppository as high as possible in the rectum.
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