February 23, 2024

Coca butter suppository Pharmaceutics I Practical

Coca butter suppository Pharmaceutics I Practical

Aim:

Preparation and evaluation of Zinc Oxide suppository using Coca butter as a suppository base

Requirement:

Evaporating dish, glass rod, Suppository mould etc.

Formula:

IngredientsQuantity GivenActivity
Zinc Oxide120 mgAstringent
Coca butterq.s toSuppository base

Procedure:

The mould was lubricated with soft soap and kept in an inverted position for some time.

The quantity of base required was calculated by taking into consideration the displacement value of Zinc oxide and the capacity of mould. zinc oxide was passed through a sieve 60 mesh

Theobroma oil was melted in an evaporating dish on a warm water bath at a temperature not exceeding 36˚C. Zinc oxide was added to the molten cocoa butter and mixed.

The mixture was poured into the pre-lubricated mould and allowed to set on an ice bath for 5 minutes. the Excess was Scrap off. Suppositories were removed and packed in boxes lined by means of a separator

Precaution: Invert lubricated mould for some time before filling.

Category:

Astringent or Laxative

Container / Storage:

Store in a cool and dry place.

Labelling directions:

For rectal use only. Use 1 at night and 1 in the morning after defecation. Insert suppository as high as possible in the rectum.


1. What is the purpose of using Zinc Oxide suppositories?

Zinc Oxide suppositories are commonly used to treat various rectal conditions, including hemorrhoids and minor irritations. The purpose of using Zinc Oxide in suppositories is primarily for its soothing and protective properties on the rectal area.

2. Why is Cocoa butter chosen as the suppository base?

Cocoa butter is an ideal choice for suppository bases due to its properties like excellent melting point, good compatibility with drugs, and minimal irritation to the rectal mucosa. Students might be asked about the specific advantages of using Cocoa butter in this formulation.

3. What is the process of preparing Zinc Oxide suppositories using Cocoa butter?

The preparation involves melting the Cocoa butter, adding Zinc Oxide to it, and homogenizing the mixture. This is followed by pouring the molten mass into suitable molds to obtain suppositories, which are then allowed to solidify.

4. How is the evaluation of Zinc Oxide suppositories conducted?

The evaluation includes assessing various parameters such as weight variation, content uniformity, melting range, hardness, and possibly in vitro release studies. Students might be asked about the specific tests conducted and their significance in evaluating the quality of the suppositories.

5. What are the potential challenges faced during the preparation of these suppositories?

Students might encounter challenges related to achieving uniform mixing of Zinc Oxide in the Cocoa butter base, controlling the melting temperature, or obtaining uniform suppositories with consistent properties. Understanding these challenges and their solutions is essential.

6. How do the properties of Zinc Oxide suppositories impact their efficacy?

The properties like melting point, hardness, and uniformity influence the suppository’s stability, ease of administration, and drug release. Understanding these connections helps in designing effective and stable formulations.

7. What are the potential applications or medical uses of Zinc Oxide suppositories?

Apart from rectal conditions, Zinc Oxide suppositories might have other therapeutic applications due to their anti-inflammatory and wound-healing properties. Exploring these broader applications can expand students’ understanding.

8. What safety considerations should be taken into account during the preparation of suppositories in a laboratory setting?

Students should be aware of safety protocols involving handling of hot substances, potential skin irritations from ingredients, and proper disposal of waste materials used in the experiment.

Pharmaceutics Practical

Syrup IP’66Liquid paraffin emulsion
Compound syrup of Ferrous PhosphateORS powder (WHO)
Piperazine citrate elixir Effervescent granules
Paracetamol pediatric elixirDusting powder
Terpin Hydrate Linctus IP’66Divided powders
Iodine Throat Paint (Mandles Paint)Glycero-gelatin suppository
Strong solution of ammonium acetateCoca butter suppository
Cresol with soap solutionZinc Oxide suppository
Aqueous Iodine SolutionSulphur ointment
Calamine lotionNon-staining-iodine ointment
Magnesium Hydroxide mixtureCarbopal gel
Aluminium hydroxide gelIodine gargle
Turpentine LinimentChlorhexidine mouthwash

First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-IF Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I TheoryBP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I TheoryBP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I TheoryBP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry TheoryBP204T Pathophysiology – Theory
BP105T Communication skills TheoryBP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial BiologyBP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics TheoryBP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology PracticalBP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I PracticalBP209P Biochemistry Practical
BP109P Pharmaceutics I PracticalBP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

Suggested readings