Liquid Paraffin Emulsion Pharmaceutics I Practical
Aim: Preparation and Evaluation of Liquid Paraffin Emulsion
Glassware’s: Beaker, glass rod, mortar & pestle, glass bottle etc.
Formula:
Ingredients | Qty Given | Activity |
Liquid paraffin | 500 ml | Laxative |
Acacia | 10x | Primary Emulsifier |
Tragacanth | x | Secondary Emulsifier |
Sodium benzoate | 5 gm | Preservative |
Vanillin | 0.5 gm | Flavouring agent |
Glycerin | 125 ml | Viscosity builder |
Chloroform | 2.5 ml | Preservative |
Purified water | q.s to 1000 ml | Vehicle |
Procedure:
Time needed: 45 minutes
Preparation and Evaluation of Liquid Paraffin Emulsion
- Dry mortar and pestle
The mortar and pestle were flamed.
- Preparation of Primary emulsion
Primary emulsion was prepared by taking oil, water and gum in the ratio of 3:2:1(Mineral oil).
Triturate in one direction only. - Preparation of Sodium benzoate solution
Sodium benzoate was dissolved in water.
- Add excipients
Sodium benzoate solution, vanillin, chloroform, and glycerin were added to the primary emulsion and triturated.
- Make up the volume
Volume is made up with purified water.
Dose: 10-30 ml
Category: Faecal softener/ Laxative
Container & Storage: Store in a well-closed container, away from light.
Labelling Directions: Shake well before use. Discard if two layers are seen.
The calculation for Primary Emulsion:
Dry gum method
Fixed Oil
Oil: Water: Gum 3 : 2: 1
Mineral Oil
Oil: Water: Gum 3 : 2: 1
Volatile Oil
Oil: Water: Gum 3 : 2: 1
Preservative
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