Iodine Gargle Pharmaceutics I Practical
Aim: Preparation and Evaluation of Iodine Gargle
Glassware’s: Beaker, glass rod, glass bottle etc.
Formula:
| Ingredients | Qty given |
| Povidone Iodine | 1.0% w/v equivalent to 0.1% w/v of available iodine) |
| Glycerol | |
| Menthol | |
| Methyl Salicylate | |
| Ethanol 96% | |
| Saccharin Sodium | |
| Purified Water | q.s to 100 ml |
Procedure:
Theory:
Povidone-iodine is a chemical complex of povidone, hydrogen iodide, and elemental iodine. It is completely soluble in cold and mild-warm water, ethyl alcohol, isopropyl alcohol, polyethene glycol, and glycerol. Free iodine, slowly liberated from the povidone-iodine (PVP-I) complex in solution, kills eukaryotic or prokaryotic cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds. This agent exhibits a broad range of microbicidal activity against bacteria, fungi, protozoa, and viruses. Slow-release of iodine from the PVP-I complex in solution minimizes iodine toxicity towards mammalian cells.
Dose: Adults, the elderly and children over 6 years of age: Use undiluted with an equal volume of warm water. Gargle or rinse with up to 10mls for up to 30 seconds without swallowing. Repeat up to four times daily, for up to 14 consecutive days, or as directed. Not to be used in children of 6 years and under
Category: For the treatment of Acute Mucosal Infections of the mouth and pharynx
e.g. gingivitis, mouth ulcers, for oral hygiene prior to, during, and after dental and oral surgery.
Labeling direction: The product should not be swallowed.
Storage: Store in a dry place below 25°C. Protect from light
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