Aluminium Hydroxide Gel Pharmaceutics I Practical
Aim:
Preparation and Evaluation of Aluminium Hydroxide gel
Requirement:
Beaker, glass rod, , glass bottle etc
Formula:
| Ingredients | Qty given | Activity |
| Aluminium Hydroxide Gel | 36 g | Antacid |
| Sorbitol | 7 ml | Preservative |
| Methyl paraben | 0.20 g | Preservative |
| Propyl paraben | 0.20 g | Preservative |
| Saccharine | 0.20 g | Sweetener |
| Peppermint Oil | 0.005 ml | Flavouring agent |
| Alcohol | 1 ml | Solubilizer |
| Purified water | 100.0ml | Vehicle |
Procedure:
The parabens, saccharine, peppermint oil was dissolved in alcohol and water.
Aluminium hydroxide gel was dispersed and mixes uniformly.
Volume made up with purified water.
Theory:
Antacids are alkaline bases used to neutralize excess gastric Hcl associated with gastric and peptic ulcers. This, in turn, inactivates pepsin which functions optimally at low pH.
Aluminum hydroxide gel is a type of antacid commonly used to relieve heartburn, indigestion, and other symptoms of excess stomach acid. It works by neutralizing the excess acid in the stomach, helping to relieve symptoms and protect the stomach lining. Aluminum hydroxide gel is available in both prescription and over-the-counter forms, and is usually taken orally, either as a liquid or a chewable tablet.
In addition to its use as an antacid, aluminum hydroxide gel is also used as an active ingredient in some vaccines to enhance the body’s immune response. It acts as an adjuvant, helping to stimulate the immune system and increase the body’s production of antibodies.
It is important to note that, like all medications, aluminum hydroxide gel can have side effects and interact with other medications. It is always best to speak with a healthcare provider before using any new medication, including antacids.
Category:
Antacid
Dose:
7.5 to 15 ml
Storage:
Store in the well-closed container below 30 °c. Avoid freezing.
Synopsis and Viva Questions
The primary purpose is to understand and demonstrate the preparation of an antacid formulation. Aluminium Hydroxide Gel is widely used as an antacid to neutralize stomach acidity and alleviate symptoms of heartburn and indigestion.
Aluminium Hydroxide Gel is preferred due to its ability to neutralize stomach acid without causing systemic alkalosis. Understanding its mechanism of action and advantages over other antacids could be part of this question.
Students might be asked to detail the ingredients used (aluminium hydroxide, water, preservatives, etc.) and the step-by-step procedure for preparing the gel, including mixing, homogenization, and packaging.
Evaluation parameters may include pH, viscosity, content uniformity, and possibly in vitro dissolution studies. Explaining these tests and their significance in determining the gel’s quality would be essential.
Students should understand potential side effects like constipation, interactions with other medications, and the importance of appropriate dosage to avoid adverse effects.
Understanding its mechanism of action, specifically how it interacts with stomach acid to neutralize it, would provide a deeper insight into its pharmacological properties.
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