Glycero Gelatin Suppository

Glycero-gelatin suppository lab experiment

Formula: 

IngredientsQuantity GivenQuantity TakenActivity
Gelatin14 partsSuppository base
Glycerine70 parts
Water16 parts

Procedure:

The mold was lubricated with Liquid Paraffin and kept in an inverted position on ice for some time.

Glycerol was heated to 100° c. (Avoid direct heating). 

Gelatin was previously soaked in water, hot glycerine was added to the soaked gelatin and heated on a water bath until a solution was complete.

The hot mass was poured into the chilled mold with stirring.

The mold was left on ice for 30 minutes. Excess was scraped off.

The mold was unscrewed, separated into two halves to remove the suppositories.

Suppositories were removed and packed in boxes lined by means of separators.

Container / Storage :

Store in a cool and dry place.

Labeling Direction :

For rectal use only

What is a suppository?

It is a solid dosage form meant to be inserted into the Body cavity like the rectum, urethra, vagina, where they melt or soften to release the drugs and produce their local or systemic effect. It comes under semi-solid preparation because it is prepared by melting all ingredients (bases and other additives along with active ingredients). All types of suppositories are melt at normal body temperature after introducing in the body cavity and produce their effect.

What are the advantages of glycero gelatin suppository?

Suppository prepared by glycero-gelatin bases is strong and translucent, unlike cocoa butter suppositories.
This base is dispersed slowly in the body cavity fluids and provides prolonged release and action of drugs.

What are the disadvantages of glycero gelatin suppository?

It absorbs moisture and promotes microbial growth, so this reason preservatives are used
The bases are show incompatibility with proteins precipitants due to the gelatin
It causes dehydration and irritation of rectal mucosa
It exerts undesirable laxative action.
It requires special storage conditions at about 10-15 0c.
Handling and manufacturing of these types of suppository are difficult.

What are labeling directions for glycero gelatin suppository?

For rectal use only

Storage for glycero gelatin suppository?

Store in a cool and dry place.

What is a formula for glycero gelatin suppository?

Gelatin
14 parts

Glycerine
70 parts

Water
16 parts

What is the composition of glycero gelatin suppository?

Gelatin, Glycerine and Water

How to prepare Glycero Gelatin Suppository

Time needed: 1 hour.

How to prepare Glycero Gelatin Suppository

  1. Lubrication of Mould

    The mold was lubricated with Liquid Paraffin and kept in an inverted position on ice for some time

  2. Heating

    Glycerol was heated to 100° c. (Avoid direct heating).

  3. Addition of Gelatin

    Gelatin was previously soaked in water, hot glycerine was added to the soaked gelatin and heated on a water bath until a solution was complete

  4. Pouring in mold

    The hot mass was poured into the chilled mold with stirring.

  5. Mold on the Ice bath

    The mold was left on ice for 30 minutes. Excess was scraped off.

  6. Removing suppositories

    The mold was unscrewed, separated into two halves to remove the suppositories.

  7. Packaging

    Suppositories were removed and packed in boxes lined by means of separators.

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