BP104T Pharmaceutical Inorganic Chemistry Theory

BP104T Pharmaceutical Inorganic Chemistry Theory Syllabus

UNIT I

Impurities in pharmaceutical substances

History of Pharmacopoeia, Sources and types of impurities, principle involved in the limit test for Chloride, Sulphate, Iron, Arsenic, Lead and Heavy metals, modified limit test for Chloride and Sulphate

General methods of preparation, assay for the compounds superscripted with asterisk (*), properties and medicinal uses of inorganic compounds belonging to the following classes

UNIT II

Acids, Bases and Buffers

Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity, calculations and methods of adjusting isotonicity.

Major extra and intracellular electrolytes

Functions of major physiological ions, Electrolytes used in the replacement therapy: Sodium chloride, Potassium chloride, Calcium gluconate and Oral Rehydration Salt (ORS), Physiological acid base balance.

Dental products

Dentifrices, role of fluoride in the treatment of dental caries, Desensitizing agents, Calcium carbonate, Sodium fluoride, and Zinc eugenol cement.

UNIT III

Gastrointestinal agents
Acidifiers

Ammonium chloride* and Dil. HCl

Antacid

Ideal properties of antacids, combinations of antacids, Sodium Bicarbonate*, Aluminum hydroxide gel, Magnesium hydroxide mixture

Cathartics

Magnesium sulphate, Sodium orthophosphate, Kaolin and Bentonite

Antimicrobials

Mechanism, classification, Potassium permanganate, Boric acid, Hydrogen peroxide, Chlorinated lime, Iodine and its preparations

UNIT IV

Miscellaneous compounds

Expectorants

Potassium iodide, Ammonium chloride*

Emetics

Copper sulphate*, Sodium potassium tartarate

Haematinics

Ferrous sulphate*, Ferrous gluconate

Poison and Antidote

Sodium thiosulphate*, Activated charcoal, Sodium nitrite

Astringents

Zinc Sulphate, Potash Alum

UNIT V

Radiopharmaceuticals

Radio activity, Measurement of radioactivity, Properties of α, β, γ radiations, Half life, radio isotopes and study of radio isotopes – Sodium iodide, Storage conditions, precautions & pharmaceutical application of radioactive substances.