Sodium fluoride: General methods of preparation, assay, properties and medicinal uses

Sodium fluoride is a colorless, odorless, crystalline salt with the chemical formula NaF. It is commonly used in the prevention of dental caries and also has some other medicinal uses. Here is a brief overview of the general methods of preparation, assay, properties, and medicinal uses of sodium fluoride:

Preparation: Sodium fluoride is typically prepared by treating hydrofluoric acid (HF) with sodium carbonate (Na2CO3) or sodium hydroxide (NaOH). The resulting solution is then evaporated and the remaining solid is dried and ground to a fine powder.

Assay: The assay of sodium fluoride typically involves titration with a standard solution of silver nitrate (AgNO3) to determine the amount of fluoride ions present in the sample. Other analytical methods, such as ion-selective electrode analysis, may also be used.

Properties: Sodium fluoride is a white crystalline solid with a melting point of 993°C and a boiling point of 1700°C. It is highly soluble in water, with a solubility of 4.24 g/100 mL at room temperature. It has a bitter taste and is toxic in high doses.

Medicinal Uses: Sodium fluoride is primarily used in the prevention of dental caries. It is added to drinking water, toothpaste, and mouthwash to promote dental health. It works by increasing the resistance of tooth enamel to acid attacks from bacteria in the mouth. Sodium fluoride may also have some therapeutic uses, such as the treatment of osteoporosis and the management of hyperthyroidism.

In conclusion, sodium fluoride is an important compound used in dental health and has some other medicinal uses as well. It is typically prepared by reacting hydrofluoric acid with sodium carbonate or sodium hydroxide, and its assay involves titration with silver nitrate. Sodium fluoride is a white crystalline solid that is highly soluble in water and has a bitter taste. Its primary medicinal use is in the prevention of dental caries.

First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-I	S Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I Theory	BP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I Theory	BP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I Theory	BP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry Theory	BP204T Pathophysiology – Theory
BP105T Communication skills Theory	BP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial Biology	BP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics Theory	BP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology Practical	BP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I Practical	BP209P Biochemistry Practical
BP109P Pharmaceutics I Practical	BP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical