Limit Test of Chloride Pharmaceutical Analysis I Practical, Lab Manual
Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration
Aim
To observe limit test for chloride impurities
Principle
The limit test for chloride is mainly used for the control of chloride impurity in inorganic substances. It depends upon the precipitation of chloride with silver nitrate in presence of dilute nitric acid and the comparison of the opalescence so obtained with standard opalescence containing a known quantity of chloride ions.
Procedure
Label two Nessler’s cylinders as Standard and Test and follow the procedure
- Pipette out 1 ml of std solution in clean Nessler’s cylinder
- Add 20 ml of distilled water
- Add 10 ml of dil HNO3
- Add 1 ml of AgNO3 solution
- Make up the volume to 50 ml with distilled water
- Mix the solution and allow to stand for 5 min.
Test solution
- Pipette out 1 ml of given sample solution in clean Nessler’s cylinder
- Add 20 ml of distilled water
- Add 10 ml of dil HNO3
- Add 1 ml of AgNO3 solution
- Make up the volume to 50 ml with distilled water
- Mix the solution and allow to stand for 5 min.
Compare the opalescence produced by the test solution with a standard solution and report your result
Reference
Indian Pharmacopoeia, ,2007,volume 1, Pg No. 67
Limit test Chlorides, Sulphate, Iron, Heavy metals * Identification tests for Anions and Cations * Prep. & std Sodium Hydroxide, Potassium Permanganate * Assay Ferrous sulphate, Calcium gluconate, Sodium chloride, Ascorbic acid, Ibuprofen * Determination of Melting point & Boiling point * Preparation Benzoic acid from Benzamide, Picric acid from Phenol * Identification & purity test Aspirin, Caffeine
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