Effervescent Granules

Formula: 

IngredientsQuantity GivenQuantity TakenActivity
Sodium sulphate200 mgSaline laxative
Citric acid monohydrate210 mgEffervescent mixture
Tartaric acid240 mgEffervescent mixture
Sodium bicarbonate500 mgEffervescent mixture

Procedure:

The powder were sifted through sieve no. 60.Mixed and  transferred to a hot porcelain dish.

The mixture was heated on a boiling water bath without stirring or pressing the powder.

Resultant mixture was sieved through sieve no. 8. Granules were dried at 40˚C.

Dried granules were passed through sieve no 14 and retained over sieve no 20.

Product was packed in wide mouth container.

Precautions:

  1. Weigh 15% extra quantity.
  2. Heat porcelain dish before using.
  3. Do not over dry the granules.

Theory                            : 

The basis of effervescent granules is a mixture of citric acid and tartaric acid with sodium bicarbonate. Usually a medicament is included and saccharin or sucrose may be added as sweetening agent.

When the patient dissolves the dose in water, the acids and bicarbonates reacts together producing carbonic acids and preparation is taken during effervescence or immediately afterwards.

Reaction:

H8C6O7.H2O + 3NaHCO3 → Na3C6H5O7 + 4H2O + 3CO2

Citric acid     Sod. Bicarbonate         Sodium Citrate

Storage :

Store in cool and dry place

Category  : Laxative

Labeling direction  :

Add 1 teaspoonful in glassful of water and take during evolution of CO2 gas.

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