Effervescent Granules

Effervescent Granules practical

Formula: 

IngredientsQuantity GivenQuantity TakenActivity
Sodium sulfate200 mgSaline laxative
Citric acid monohydrate210 mgEffervescent mixture
Tartaric acid240 mgEffervescent mixture
Sodium bicarbonate500 mgEffervescent mixture

Time needed: 2 hours.

How to prepare effervescent granules, effervescent powders, or effervescent salts?

  1. Sieving the powder

    The powder was sifted through sieve no. 60

  2. Mixing and Transfer of Powder

    The powder is mixed and transferred to a hot porcelain dish

  3. Heating

    The mixture was heated on a boiling water bath without stirring or pressing the powder.

  4. Sieving of mixture

    The resultant mixture was sieved through sieve no. 8

  5. Drying of Granules

    Granules were dried at 40˚C.

  6. Sieving of Dried granules

    Dried granules were passed through sieve no 14 and retained over sieve no 20.

  7. Packaging of granules

    The product was packed in a wide-mouth container

What is Effervescent Granules?

Effervescent granules are the specially prepared solid dosage form of medicament, meant for internal use. They contain a medicament mixed with citric acid, tartaric acid, and sodium bicarbonate. Sometimes saccharin or sucrose may be added as a sweetening agent. Before administration, the desired quantity is dissolved in water, the acid and bicarbonate react together producing effervescence. The carbonated water produced from the release of carbon dioxide serves to mask the bitter and saline taste of drugs. Moreover, carbon dioxide stimulates the flow of gastric juice and helps in the absorption of medicament.

Methods of preparation of effervescent granules?

There are two methods of preparation of effervescent granules:
1) Heat method
A large porcelain or stainless steel evaporating dish is placed over the boiling water bath. The dish must be sufficiently hot before transferring the powder into it, to ensure the liberation of the water of the crystallization from the citric acid. If heating of the dish is delayed, the powder which is added to it will heat up slowly and the liberated water of crystallization will go on evaporating simultaneously. As a result, sufficient water will not be available to make a coherent mass.
2) Wet method
In this method, the mixed ingredients are moistened with a non-aqueous liquid (e.g. alcohol)to prepare a coherent mass which is then passed through a number 8 sieve and dried in an oven at a temperature not exceeding 60*C . The dried granules are again passed through the sieve to break the lumps which may be formed during drying. The dried granules are packed in air-tight containers.

How to take effervescent granules?

Add 1 teaspoonful in a glassful of water and take during the evolution of CO2 gas.

What is the reaction involved in effervescent granules?

H8C6O7.H2O + 3NaHCO→ Na3C6H5O7 + 4H2O + 3CO2

What is the category of Sodium sulfate effervescent granules?

Laxative
Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have

What are laxatives, purgatives, or aperients?

Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have

What are effervescent granules, effervescent powders or effervescent salts?

Effervescent salts are granules or coarse powders containing a medicinal agent in a dry mixture, usually composed of sodium bicarbonate, citric acid, and tartaric acid. When the salts are added to water, the acids and the base react to liberate carbon dioxide gas, thereby causing “effervescence”.

What is the Labeling direction for effervescent granules, effervescent powders or effervescent salts?

Add 1 teaspoonful in a glassful of water and take during the evolution of CO2 gas.

Precautions to be taken while preparing effervescent granules, effervescent powders or effervescent salts?

Weigh 15% extra quantity.
Heat porcelain dish before using.
Do not over-dry the granules.

Formula for Sodium sulphate effervescent granules?

Sodium sulfate
200 mg
Saline laxative

Citric acid monohydrate
210 mg
Effervescent mixture

Tartaric acid
240 mg
Effervescent mixture

Sodium bicarbonate
500 mg
Effervescent mixture

Theory                            : 

The basis of effervescent granules is a mixture of citric acid and tartaric acid with sodium bicarbonate. Usually, a medicament is included and saccharin or sucrose may be added as a sweetening agent.

When the patient dissolves the dose in water, the acids and bicarbonates react together producing carbonic acids, and preparation is taken during effervescence or immediately afterward.

Reaction:

H8C6O7.H2O + 3NaHCO3 → Na3C6H5O7 + 4H2O + 3CO2

Citric acid     Sod. Bicarbonate         Sodium Citrate

Storage :

Store in a cool and dry place

Category: Laxative

Labeling direction  :

Add 1 teaspoonful in a glassful of water and take during the evolution of CO2 gas.

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