Buffers in pharmaceutical systems
There are different types of buffers that are commonly used in pharmaceutical systems. Some of the most commonly used buffers in Pharmaceutical Analysis include:
- Acetate buffer: Acetate buffer is a weak acid buffer that is commonly used in Pharmaceutical Analysis. It is prepared by mixing acetic acid and sodium acetate and is commonly used in the formulation of pharmaceutical products and in analytical methods.
- Phosphate buffer: Phosphate buffer is another common buffer used in pharmaceutical systems. It is prepared by mixing sodium phosphate and di-sodium phosphate and is commonly used in analytical methods such as high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE).
- Citrate buffer: Citrate buffer is a weak acid buffer that is commonly used in the formulation of pharmaceutical products and in analytical methods. It is prepared by mixing citric acid and sodium citrate.
- Tris buffer: Tris buffer is a weak base buffer that is commonly used in biochemical and pharmaceutical applications. It is prepared by mixing tris(hydroxymethyl)aminomethane and hydrochloric acid or sodium hydroxide.
- MES buffer: MES buffer is a weak acid buffer that is commonly used in pharmaceutical research and development. It is prepared by mixing 2-(N-morpholino)ethanesulfonic acid and sodium hydroxide.
- MOPS buffer: MOPS buffer is a weak acid buffer that is commonly used in biochemical and pharmaceutical applications. It is prepared by mixing 3-(N-morpholino)propanesulfonic acid and sodium hydroxide.
In addition to the above-mentioned buffers, there are several other buffer systems that are used in pharmaceutical systems depending on the specific application and pH requirements. The choice of buffer depends on the specific requirements of the system and the pH range that needs to be maintained.
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