Magnesium Hydroxide mixture experiment preparation and evaluation, Milk of magnesia
Aim:
Preparation and Evaluation of Magnesium Hydroxide mixture / Milk of magnesia
Glassware: Beaker, glass rod, mortar & pestle, glass bottle etc.
Formula:
| Ingredients | Qty Given | Activity |
| Magnesium Sulphate | Formation of Magnesium Hydroxide | |
| Sodium Hydroxide | ||
| Light Magnesium oxide | ||
| Purified water freshly boiled and cooled | q.s to 1000 ml | Vehicle |
Procedure:
Time needed: 1 hour.
How to prepare Magnesium Hydroxide mixture/ How to prepare Milk of magnesia
- Preparation of Sodium hydroxide
Sodium hydroxide was dissolved in purified water.
- Preparation of smooth cream
Light magnesium oxide was triturated with this solution to form a smooth cream.
- Mixing both solutions
Pour this suspension in a thin stream into a solution of the magnesium sulfate in purified water, stirring continuously during the mixing.
- Set mixture aside
The mixture is set aside in a closed container for 48 hrs
- Washing
Allow the precipitate to subside, remove the clear liquid, and wash the precipitate with purified water until the washings give only a slight reaction for sulfate. Test with barium chloride solution. Mix the washed precipitate with purified water
- Make up the volume
Add sufficient purified water to produce the required volume.
Theory:
MgO +H2O Mg (OH)2
This is a Hydration reaction. This is very slow reaction
Mg SO4 +2 NaOH Mg (OH)2 + Na2SO4
Precipitation reaction by double decomposition
All sulphate ions ( Na2SO4) must be removed as they enhance the peristalsis of the intestine.
Precautions:
Avoid giving it to patients with hypophosphatemia and impairment of renal function.
Do not co-administer with antidepressant and anti-epileptic drugs.
Definitions:
O Milk of magnesia: It is an antacid that consists of a suspension of magnesium hydroxide in water. Milk-like appearance is giving a name of magnesia
O Laxative: The agents which loosen stools and increase bowel movement.
O Antacid: The agents or drugs which neutralize the excess secretion of hydrochloric acid
O Preservative: The chemical substances used in various pharmaceutical dosage forms and cosmetic preparations to prevent or inhibit microbial growth.
O Flavouring agent: The agents are usually added in pharmaceutical dosage form to give flavour to the pharmaceutical formulation.
O Vehicle: Vehicles or solvents are the medium in which ingredients of a formulation are Dissolved, suspended or dispersed.
Information
Category: Laxative (8-16 ml) and antacid (1-4 ml)
Container & storage: Well closed container in a cool place
Labelling Direction: Shake well before use
What is the other name of magnesium hydroxide?
Magnesium hydroxide mixture is also known as Milk of magnesia or magnesium(2+) hydroxide
Magnesium hydroxide mixture is also called as Milk of magnesia
Laxative (8-16 ml) and antacid (1-4 ml)
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