Assay of Ibuprofen by Alkalimetry: Pharmaceutical Chemistry Practical

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Limit test Chlorides, Sulphate, Iron, Heavy metals * Identification tests for Anions and Cations * Prep. & std Sodium Hydroxide, Potassium Permanganate * Assay Ferrous sulphate, Calcium gluconate, Sodium chloride, Ascorbic acid, Ibuprofen * Determination of Melting point & Boiling point * Preparation Benzoic acid from Benzamide, Picric acid from Phenol * Identification & purity test Aspirin, Caffeine

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Aim:

To perform the Assay of Ibuprofen IP by Alkalimetry

Apparatus:

Burette (50ml), pipette (10ml&25ml), beaker (100ml), conical flask (250 ml), measuring cylinder (100ml), glass funnel (small) etc.

Chemicals:

Ibuprofen, ethanol, Sodium hydroxide, (apporx.1M), phenolphthalein.

Procedure:

Standardization of sodium hydroxide.

1. Weigh accurately 5g of potassium hydrogen phthalate.

2. Dissolve it in 75ml of carbon dioxide-free water.

3. Add 0.1ml of phenolphthalein solution as an indicator.

4. Fill the burette with the given sodium hydroxide solution.

5. Remove the air bubble and adjust the zero level.

6. Titrate the solution in a conical flask by running the solution from the burette till the colour changes from colourless to pink.

7. Report the reading by repeating it three times and calculating the molarity of sodium hydroxide.

Procedure:

Transfer accurately about 0.38 g powdered tablet that is equivalent to 0.2 g of ibuprofen into a conical flask.

Add 25 ml of ethanol then shake for 5 minutes and filter.

Titrate the filtrate against 0.1 N NaOH volumetric solution using phenol red as an indicator

Assay procedure:

Weigh accurately about 0.4 g of ibuprofen dissolved in 100 ml with ethanol (96%) previously neutralized to phenolphthalein solution. The solution was titrated with 0.1M sodium hydroxide to an endpoint with phenolphthalein solution as the indicator. The content of ibuprofen was calculated if each ml of 0.1M sodium hydroxide is equivalent to 0.02063 g of C₁₃H₁₈O_2.

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F Y D Pharm & S Y D Pharm Notes, Books, Syllabus, PDF, Videos

First Year D Pharm	Second Year D Pharm
ER20-11T Pharmaceutics Theory	ER20-21T Pharmacology Theory
ER20-11P Pharmaceutics Practical	ER20-21P Pharmacology Practical
ER20-12T Pharmaceutical Chemistry Theory	ER20-22T Community Pharmacy & Management Theory
ER20-12P Pharmaceutical Chemistry Practical	ER20-22P Community Pharmacy & Management Practical
ER20-13T Pharmacognosy Theory	ER20-23T Biochemistry & Clinical Pathology Theory
ER20-13P Pharmacognosy Practical	ER20-23P Biochemistry & Clinical Pathology Practical
ER20-14T Human Anatomy Physiology Theory	ER20-24T Pharmacotherapeutics Theory
ER2014P Human Anatomy Physiology Practical	ER20-24P Pharmacotherapeutics Practical
ER20-15T Social Pharmacy Theory	ER20-25T Hospital & Clinical Pharmacy Theory
ER20-15P Social Pharmacy Practical	ER20-25P Hospital & Clinical Pharmacy Practical
	ER20-26T Pharmacy Law & Ethics

Suggested readings:

• Preparation and standardization of Sodium hydroxide Standard solution
• Magnesium Hydroxide mixture / Milk of magnesia
• Aluminium Hydroxide Gel Pharmaceutics I Practical
• Assay of Ammonium chloride Pharmaceutical Analysis I Practical
• Assay of Chlorpheniramine maleate

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Recommended readings:

• Pharmaceutics I Practical
• Pharmaceutical Analysis I Theory