Aspirin: Identification and test for purity: Pharmaceutical Chemistry Practical
Limit test Chlorides, Sulphate, Iron, Heavy metals * Identification tests for Anions and Cations * Prep. & std Sodium Hydroxide, Potassium Permanganate * Assay Ferrous sulphate, Calcium gluconate, Sodium chloride, Ascorbic acid, Ibuprofen * Determination of Melting point & Boiling point * Preparation Benzoic acid from Benzamide, Picric acid from Phenol * Identification & purity test Aspirin, Caffeine
Aim:
To perform and report identification test on the given sample of Aspirin or Acetyl Salicylic Acid as per Indian Pharmacopoeia
Apparatus:
Glasswares:
Thiel’s tube, Test tubes, Capillary.
Chemicals:
Sodium hydroxide solution, Ferric chloride solution, Alcohol (95%), Sulphuric acid, Chloroform, Ether.
Theory:
Aspirin, also known as acetylsalicylic acid (ASA) and chemically it is acetoxybenzoic acid, is a medication used to reduce pain, fever, or inflammation. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever.
Procedure for Description:
Observe the given drug critically for the following description. The drug is crystals or crystalline powder, colourless or white, odourless or almost odourless as per I.P.
Procedure for Solubility:
Perform solubility test in the different solvents. The drug is sparingly soluble in water, freely soluble in alcohol, soluble in chloroform and in ether, and slightly soluble in water.
Procedure for Identification Solubility:
A. Boil about 0.5 g of drug with 10 ml of sodium hydroxide solution for 3 minutes, cool and add 10 ml of dilute sulphuric acid -a white crystalline precipitate is produced, it has the odour of acetic acid. Filter, dissolve the precipitate in about 2 ml of water and add ferric chloride solution, a deep violet colour is produced.
B. To the filtrate obtained in test A add 3ml of alcohol (95%) and 3ml of sulphuric acid and warm; the odour of ethyl acetate is perceptible.
C. Determination of Melting Point: The drug melts at about 142°C
Observation Table:
Report on Identification tests on a sample of Aspirin
Result:
The given sample is found to be of ______________with melting point 147°C
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