Assay of Ammonium chloride Pharmaceutical Analysis I Practical
Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration
To determine the percent content of Ammonium chloride in the given sample.
It is estimated by the alkalimetry method. An accurately weighed quantity of the sample is dissolved in water to liberate HCl which is directly titrated with 0.1M NaOH using phenolphthalein solution as an indicator. Neutralized formaldehyde solution is added to fix the ammonia as Hexamine, otherwise, it will interfere with titrant (Alkali).
Ammonium Chloride contains not less than 99.0 per cent and not more than 100.5 per cent of NH4Cl, calculated on a dried basis.
Weigh accurately about 0.1 g, dissolve in 20 ml of water and add a mixture of 5 ml of formaldehyde solution, previously neutralised to dilute phenolphthalein solution, and 20 ml of water.
After 2 minutes, titrate slowly with 0.1 M sodium hydroxide using a further 0.2 ml of dilute phenolphthalein solution as an indicator.
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