Assay of Ammonium chloride Pharmaceutical Analysis I Practical

Assay of Ammonium chloride Pharmaceutical Analysis I Practical

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Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration

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Aim

To determine the percent content of Ammonium chloride in the given sample.

Principle

It is estimated by the alkalimetry method. An accurately weighed quantity of the sample is dissolved in water to liberate HCl which is directly titrated with 0.1M NaOH using phenolphthalein solution as an indicator. Neutralized formaldehyde solution is added to fix the ammonia as Hexamine, otherwise, it will interfere with titrant (Alkali).

Standard

Ammonium Chloride contains not less than 99.0 per cent and not more than 100.5 per cent of NH4Cl, calculated on a dried basis.

Procedure

Weigh accurately about 0.1 g, dissolve in 20 ml of water and add a mixture of 5 ml of formaldehyde solution, previously neutralised to dilute phenolphthalein solution, and 20 ml of water.

After 2 minutes, titrate slowly with 0.1 M sodium hydroxide using a further 0.2 ml of dilute phenolphthalein solution as an indicator.

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First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-I	S Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I Theory	BP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I Theory	BP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I Theory	BP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry Theory	BP204T Pathophysiology – Theory
BP105T Communication skills Theory	BP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial Biology	BP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics Theory	BP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology Practical	BP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I Practical	BP209P Biochemistry Practical
BP109P Pharmaceutics I Practical	BP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

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Suggested readings:

• Strong solution of ammonium acetate
• Preparation and standardization of Ceric ammonium sulfate standard solution
• BP104T Pharmaceutical Inorganic Chemistry Theory Syllabus
• Limit Test of Chloride Pharmaceutical Analysis I Practical, Lab Manual
• BioMarin announces study of gene therapy to treat severe haemophilia A with valoctocogene roxaparvovec
• b pharmacy syllabus

Recommended readings:

• BIOSTATISTICS AND RESEARCH METHODOLOGY Theory

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IPC Nagpur