Preparation and standardization of Sodium hydroxide Standard solution

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Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration

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Aim

To Prepare and standardize 0.1M Sodium hydroxide Standard solution

Principle

The standardization is based on the neutralization reaction between potassium hydrogen phthalate and sodium hydroxide in equimolar concentration using phenolphthalein solution as an indicator. The endpoint is the appearance of permanent pale pink color.

Procedure

Preparation of 0.1M Sodium hydroxide Standard solution

Dissolve ____ g of sodium hydroxide in sufficient carbon dioxide-free water to produce 1000 ml.

Reference:

Indian Pharmacopoeia, 2007, Volume1, Pg. no 316

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Limit test Chlorides, Sulphate, Iron, Heavy metals * Identification tests for Anions and Cations * Prep. & std Sodium Hydroxide, Potassium Permanganate * Assay Ferrous sulphate, Calcium gluconate, Sodium chloride, Ascorbic acid, Ibuprofen * Determination of Melting point & Boiling point * Preparation Benzoic acid from Benzamide, Picric acid from Phenol * Identification & purity test Aspirin, Caffeine

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First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-I	S Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I Theory	BP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I Theory	BP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I Theory	BP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry Theory	BP204T Pathophysiology – Theory
BP105T Communication skills Theory	BP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial Biology	BP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics Theory	BP207P Human Anatomy and Physiology II Practical
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F Y D Pharm & S Y D Pharm Notes, Books, Syllabus, PDF, Videos

First Year D Pharm	Second Year D Pharm
ER20-11T Pharmaceutics Theory	ER20-21T Pharmacology Theory
ER20-11P Pharmaceutics Practical	ER20-21P Pharmacology Practical
ER20-12T Pharmaceutical Chemistry Theory	ER20-22T Community Pharmacy & Management Theory
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ER20-13P Pharmacognosy Practical	ER20-23P Biochemistry & Clinical Pathology Practical
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ER2014P Human Anatomy Physiology Practical	ER20-24P Pharmacotherapeutics Practical
ER20-15T Social Pharmacy Theory	ER20-25T Hospital & Clinical Pharmacy Theory
ER20-15P Social Pharmacy Practical	ER20-25P Hospital & Clinical Pharmacy Practical
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Suggested readings:

• BP108P Pharmaceutical Analysis I Practical
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