Preparation and standardization of Sodium hydroxide Standard solution
Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration
To Prepare and standardize 0.1M Sodium hydroxide Standard solution
The standardization is based on the neutralization reaction between potassium hydrogen phthalate and sodium hydroxide in equimolar concentration using phenolphthalein solution as an indicator. The endpoint is the appearance of permanent pale pink color.
Preparation of 0.1M Sodium hydroxide Standard solution
Dissolve ____ g of sodium hydroxide in sufficient carbon dioxide-free water to produce 1000 ml.
Time needed: 20 minutes.
Standardization of 0.1M Sodium hydroxide Standard solution
- Weigh potassium hydrogen phthalate
Weigh accurately about 0.5 g of potassium hydrogen phthalate, previously powdered and dried at 120° for 2 hours
- Dissolve in Water
Dissolve in 75 ml of carbon dioxide-free water
- Addition of phenolphthalein solution
Add 0.1 ml of phenolphthalein solution
- Titration with the sodium hydroxide solution
Titrate with the sodium hydroxide solution until a permanent pink color is produced.
Indian Pharmacopoeia, 2007, Volume1, Pg. no 316
Limit test Chlorides, Sulphate, Iron, Heavy metals * Identification tests for Anions and Cations * Prep. & std Sodium Hydroxide, Potassium Permanganate * Assay Ferrous sulphate, Calcium gluconate, Sodium chloride, Ascorbic acid, Ibuprofen * Determination of Melting point & Boiling point * Preparation Benzoic acid from Benzamide, Picric acid from Phenol * Identification & purity test Aspirin, Caffeine
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