February 22, 2024

Preparation and standardization of Sodium thiosulfate standard solution

Preparation and standardization of Sodium thiosulfate standard solution

Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration


To Prepare and standardize 0.01 M sodium thiosulphate standard solution


The principle of standardization of sodium thiosulphate is based on redox iodometric titration with potassium iodate (or potassium bromate) as a primary standard. Potassium iodate a strong oxidizing agent is treated with excess potassium iodide in acidic media which liberates iodine which is back titrated with sodium thiosulphate


Preparation of 0.1 M Sodium thiosulfate standard solution

Dissolve____ g of sodium thiosulphate and 0.2 g of sodium carbonate in carbon dioxide-free water and dilute to 1000 ml with the same solvent.

Standardization of 0.1 M Sodium thiosulfate solution Dissolve 0.200 g of potassium bromate, weighed accurately, in sufficient water to produce 250.0 ml. To 50.0 ml of this solution add 2 g of potassium iodide and 3 ml of 2 M hydrochloric acid and titrate with the sodium thiosulphate solution using the starch solution, added towards the end of the titration, as an indicator until the blue colour is discharged.


Indian Pharmacopoeia 2014; Vol. 1; Pg. No. 316

First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-IS Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I TheoryBP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I TheoryBP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I TheoryBP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry TheoryBP204T Pathophysiology – Theory
BP105T Communication skills TheoryBP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial BiologyBP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics TheoryBP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology PracticalBP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I PracticalBP209P Biochemistry Practical
BP109P Pharmaceutics I PracticalBP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

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