Preparation and standardization of Potassium permanganate standard solution
Pharmaceutical Analysis I Practical: Limit test for (1) Chloride (2) Sulphate (3) Iron (4) Arsenic Preparation and standardisation of (1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate (4) Potassium permanganate (5) Ceric ammonium sulphate Assay (1) Ammonium chloride (2) Ferrous sulphate(3) Copper sulphate (4) Calcium gluconate (5) Hydrogen peroxide (6) Sodium benzoate (7) Sodium Chloride Determination of Normality (1) Conductometric titration of strong acid against a strong base (2) Conductometric titration of strong acid and weak acid against a strong base (3) Potentiometric titration
Aim
To Prepare and standardize 0.02 M Potassium permanganate standard solution
Principle
0.02 M (M/50) potassium permanganate solution is standardized by titration against the primary standard such as sodium oxalate or arsenic trioxide or oxalic acid or by using another secondary standard like sodium thiosulphate solution.
Potassium permanganate reacts with potassium iodide in highly acidic conditions to liberate iodine. This iodine is titrated with sodium thiosulphate using starch as an indicator. Starch if added initially, degrades in highly acidic conditions, also as the concentration of iodine is very high at the initial stage, starch may form an irreversible complex with iodine, so it is added towards the end of the titration
Procedure
Preparation of0.02 MPotassium permanganate standard solution
Dissolve ____ g of potassium permanganate in 1000 ml of water, heat on a water bath for 1hour, allow to stand for 2 days, and filter through glass wool.
Time needed: 30 minutes
Standardization of 0.02 M Potassium permanganate solution
- Addition of potassium iodide
To 25.0 ml of the solution in a glass-stoppered flask add 2 g of potassium iodide
- Addition of sulphuric acid
Add 10 ml of 1 M sulphuric acid
- Titration of liberated iodine
Titrate the liberated iodine with 0.1 M sodium thiosulphate, using 3 ml of starch solution, added towards the end of the titration, as an indicator.
- Blank determination
Perform a blank determination and make the necessary correction.
Reference:
Indian Pharmacopoeia 2014 Vol. 1 Pg no. 838
Limit test Chlorides, Sulphate, Iron, Heavy metals * Identification tests for Anions and Cations * Prep. & std Sodium Hydroxide, Potassium Permanganate * Assay Ferrous sulphate, Calcium gluconate, Sodium chloride, Ascorbic acid, Ibuprofen * Determination of Melting point & Boiling point * Preparation Benzoic acid from Benzamide, Picric acid from Phenol * Identification & purity test Aspirin, Caffeine
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