February 22, 2024

Assay of Ibuprofen: Medicinal Chemistry Practical

Assay of Ibuprofen: Medicinal Chemistry Practical

BP406P Medicinal Chemistry I Practical


Aim

To carry out the assay of Ibuprofen tablet

REFERENCE:

1.   Indian Pharmacopoeia 2018 page no:2261-65.

REQUIREMENTS:

Ibuprofen,0.1N sodium hydroxide solution, phenolphthalein indicator, 0.1N oxalic acid solution, conical flask, burette, beaker etc.

PRINCIPLE:

Ibuprofen is determined by neutralization titration in which free carboxylic group is titrated with sodium hydroxide solution using phenolphthalein indicator. The amount of sodium hydroxide consumed in the reaction indicates the amount of ibuprofen present in the sample.

PROCEDURE:

PREPARATION AND STANDARDIZATION OF STANDARD SOLUTIONS

SODIUM HYDROXIDE,XM

Solutions of any molarity xM may be prepared by dissolving 40x g of Sodium hydroxide in sufficient water to produce 1000ml.

STANDARDIZATION OF 0.1M SODIUM HYDROXIDE SOLUTION

Weighed accurately about 5g of potassium hydrogen phthalate previously dried at 1200C for two hours dissolve in 75ml of carbon dioxide free water.

Added  0.1ml of phenolphthalein solution and titrate with the sodium hydroxide until a permanent pink color is produced.

Each ml of 0.1M NaOH equivalent to 0.02042g of potassium hydrogen phthalate.

Phenolphthalein solution

A 1.0%w/v solution of phenolphthalein in ethanol(95%).

PROCEDURE:

Weighed and powdered 20 tablets.

Weighed a quantity of powder containing about 0.4g of ibuprofen, dissolve in 100ml of ethanol (95%) and titrated with 0.1M sodium hydroxide using 0.2ml of phenolphthalein solution as indicator. Perform a blank determination and make necessary correction.

Each ml of 0.1 M sodium hydroxide is equivalent to 0.02063 g of C13 H18 O2

REPORT

The given sample contains ………………….  mg of Ibuprofen.


Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

S Y B Pharm Sem IIIS Y B Pharm Sem IV
BP301T Pharmaceutical Organic Chemistry II TheoryBP401T Pharmaceutical Organic Chemistry III Theory
BP302T Physical Pharmaceutics I TheoryBP402T Medicinal Chemistry I Theory
BP303T Pharmaceutical Microbiology TheoBP403T Physical Pharmaceutics II Theory
BP304T Pharmaceutical Engineering TheoryBP404T Pharmacology I Theory
BP305P Pharmaceutical Organic Chemistry II PracticalBP405T Pharmacognosy I Theory
BP306P Physical Pharmaceutics I PracticalBP406P Medicinal Chemistry I Practical
BP307P Pharmaceutical Microbiology PracticalBP407P Physical Pharmaceutics II Practical
BP308P Pharmaceutical Engineering PracticalBP408P Pharmacology I Practical
BP409P Pharmacognosy I Practical

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