Assay of aspirin: Medicinal Chemistry Practical

BP406P Medicinal Chemistry I Practical

AIM:

To perform Assay of aspirin.

REFERENCE:

1. A textbook of Medicinal Chemistry-I,Pragi Arora,Varun Arora,Davinder Kumar,Page no:282,283.
2. Indian Pharmacopoeia Volume I  1996, Page No:69,70.
3. Pharmaceutical titrimetric analysis theory and practical,A.A Napoleon,Page No:11-17.

REQUIREMENTS:

Aspirin, Sodium hydroxide solution (0.5N),Hydrochloric acid (0.5N),Phenol red indicator, Burette, Conical flask, Funnel, Beaker etc.

PROCEDURE:

1. STANDARDIZATION OF 0.5M  HYDROCHLORIC ACID

Weighed accurately 0.75g of Anhydrous sodium carbonate previously heated at 2700C. Dissolve in 100 ml of water and added 0.1ml of methyl red solution. Added the titrant slowly from the burette with constant stirring until the solution becomes faintly pink.

Heated the solution.Cool and continue.If pink colour fades on heating continue this process until a faint pink colour is no longer affected by continous boiling.

Each ml of 0.5M HCl = 0.026495g of Na2CO3

ASSAY OF ASPIRIN PROCEDURE

Weighed accurately 1.5g of aspirin and dissolved in 15ml ethanol added 50ml of 0.5M sodium hydroxide boil gently for 10 minutes, cool and titrated the excess alkali with 0.5M HCl using phenol red solution as indicator.

Perform a blank determination the difference between the titration represent the volume of sodium hydroxide consumed.

Each ml of 0.05M NaOH = 0.04504g of C9H8O

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Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

S Y B Pharm Sem III	S Y B Pharm Sem IV
BP301T Pharmaceutical Organic Chemistry II Theory	BP401T Pharmaceutical Organic Chemistry III Theory
BP302T Physical Pharmaceutics I Theory	BP402T Medicinal Chemistry I Theory
BP303T Pharmaceutical Microbiology Theo	BP403T Physical Pharmaceutics II Theory
BP304T Pharmaceutical Engineering Theory	BP404T Pharmacology I Theory
BP305P Pharmaceutical Organic Chemistry II Practical	BP405T Pharmacognosy I Theory
BP306P Physical Pharmaceutics I Practical	BP406P Medicinal Chemistry I Practical
BP307P Pharmaceutical Microbiology Practical	BP407P Physical Pharmaceutics II Practical
BP308P Pharmaceutical Engineering Practical	BP408P Pharmacology I Practical
	BP409P Pharmacognosy I Practical

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Suggested readings

• Aspirin: Identification and test for purity: Pharmaceutical Chemistry Practical
• BP406P Medicinal Chemistry I Practical
• Preparation and evaluation of Aspirin tablets
• <strong>Synthesis </strong><strong>of Aspirin Assisted by Microwave Oven</strong>
• BP607P Medicinal Chemistry III Practical

Recommended readings:

• Pharmaceutics I Practical
• Pharmaceutical Analysis I Theory