Synthesis of Aspirin Assisted by Microwave Oven
BP607P Medicinal Chemistry III Practical : I Preparation of drugs Sulphanilamide * 7-Hydroxy, 4-methyl coumarin * Chlorobutanol * Triphenyl imidazole * Tolbutamide * Hexamine II Assay of drugs Isonicotinic acid hydrazide * Chloroquine * Metronidazole * Dapsone * Chlorpheniramine maleate * Benzyl penicillin III Microwave irradiation technique Synthesis of Phenytoin by Microwave * Synthesis of Aspirin by Microwave IV Drawing structures and reactions using chem draw®
Aim:
To Prepare and Submit aspirin from Salicylic acid and Calculate the Percentage Yield.
Principle:
The microwave region of Electro-Magnetic spectrum light between IR irradiation and frequency corresponding to the wavelength of 1cm-1 to 1m. The organic compound can be heated by applying energy in the form of microwave high-frequency IR irradiation. The use of this technique can have substantial saving time for laboratory synthesis of drugs and chemicals.
Aspirin is prepared from Salicylic acid, in this method salicylic acid reacts with acetic anhydride in the presence of sulphuric acid to form the crystalline nature of aspirin.
Reaction
Procedure:
Two reaction consist of a two-neck flask with magnetic stir bar, temperature, sensor and intensive cooler. A mixture of salicylic acid and acetic anhydride is filled in the reaction flask and three drop of conc. Sulphuric Acid are added the apparatus is installed by means of a glass tube in the microwave system. Standard refluxing apparatus for microwave system.
The reaction mixture is heated under stirring for 90 sec. with 900 W to 140 C, during the following cooling down the clear yellowish solidified to a compact white crystalline mass
Melting Point: 135 C
Use:
Anti-inflammatory agent
Result:
Aspirin was synthesised and reported the following
- Theoretical yield =
- Practical yield =
- Percentage yield =
Third Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
Suggested readings:
Recommended readings:
