BP301T. PHARMACEUTICAL ORGANIC CHEMISTRY –II Theory

Pharmaceutical Organic Chemistry II Syllabus

Pharmaceutical Organic Chemistry II

UNIT I Benzene and its derivatives

A. Analytical, synthetic and other evidence in the derivation of the structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule

B. Reactions of benzene – nitration, sulphonation, halogenation reactivity, Friedelcrafts alkylation- reactivity, limitations,
Friedel crafts acylation.

C. Substituents, the effect of substituents on reactivity and orientation of monosubstituted benzene compounds towards electrophilic substitution reaction

D. Structure and uses of DDT, Saccharin, BHC, and Chloramine

UNIT II Phenols

Acidity of phenols, the effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols

Aromatic Amines

Basicity of amines, the effect of substituents on basicity, and synthetic uses of aryl diazonium salts

Aromatic Acids* –Acidity, the effect of substituents on acidity, and important reactions of benzoic acid.

UNIT III Fats and Oils

a. Fatty acids – reactions.

b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.

c. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and the principle involved in their determination.

UNIT IV Polynuclear hydrocarbons:

a. Synthesis, reactions

b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

UNIT V Cyclo alkanes

Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only

Pharmaceutical Organic Chemistry II Recommended Books (Latest Editions)

  1. Organic Chemistry byMorrison and Boyd
  2. Organic Chemistry by I.L. Finar , Volume-I
  3. Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.
  4. Organic Chemistry by P.L.Soni
  5. Practical Organic Chemistry byMann and Saunders.
  6. Vogel’s text book of Practical Organic Chemistry
  7. Advanced Practical organic chemistry by N.K.Vishnoi.

Second Year B Pharm

Semester III

Theory

BP301T Pharmaceutical Organic Chemistry II – Theory : Click here for Detailed syllabus
BP302T Physical Pharmaceutics I –Theory : Click here for Detailed syllabus
BP303T Pharmaceutical Microbiology – Theory : Click here for Detailed syllabus
BP304T Pharmaceutical Engineering – Theory : Click here for Detailed syllabus

Practical

BP305P Pharmaceutical Organic Chemistry II – Practical : Click here for Detailed syllabus
BP306P Physical Pharmaceutics I – Practical : Click here for Detailed syllabus
BP307P Pharmaceutical Microbiology – Practical : Click here for Detailed syllabus
BP308P Pharmaceutical Engineering – Practical : Click here for Detailed syllabus