BP501T Medicinal Chemistry II Theory

Medicinal Chemistry II Theory Syllabus

UNIT I

Antihistaminic agents: Histamine, receptors and their distribution in the human body

H1–antagonists:
Diphenhydramine hydrochloride, Dimenhydrinate, Doxylamines cuccinate, Clemastine fumarate, Diphenylphyraline hydrochloride, Tripelenamine hydrochloride, Chlorcyclizine hydrochloride, Meclizine hydrochloride, Buclizine hydrochloride, Chlorpheniramine maleate, Triprolidine hydrochloride, Phenidamine tartrate, Promethazine hydrochloride*, Trimeprazine tartrate, Cyproheptadine hydrochloride, Azatidine maleate, Astemizole, Loratadine, Cetirizine, Levocetrazine Cromolyn sodium

H2-antagonists: Cimetidine*, Famotidine, Ranitidine.

Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole

Anti-neoplastic agents:

Alkylating agents: Meclorethamine*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa

Antimetabolites: Mercaptopurine, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate, Azathioprine

Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin

Plant products: Etoposide, Vinblastin sulfate, Vincristine sulfate

Miscellaneous: Cisplatin, Mitotane.

UNIT II

Anti-anginal: Vasodilators: Amyl nitrite, Nitroglycerin, Pentaerythritol tetranitrate, Isosorbide dinitrate, Dipyridamole.

Calcium channel blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.

Diuretics: Carbonic anhydrase inhibitors: Acetazolamide*, Methazolamide, Dichlorphenamide.

Thiazides: Chlorthiazide*, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide,

Loop diuretics: Furosemide*, Bumetanide, Ethacrynic acid.

Potassium-sparing Diuretics: Spironolactone, Triamterene, Amiloride.

Osmotic Diuretics: Mannitol

Anti-hypertensive Agents: Timolol, Captopril, Lisinopril, Enalapril, Benazepril hydrochloride, Quinapril hydrochloride, Methyldopate hydrochloride,* Clonidine hydrochloride, Guanethidine monosulphate, Guanabenz acetate, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine hydrochloride.

UNIT III

Anti-arrhythmic Drugs: Quinidine sulfate, Procainamide hydrochloride, Disopyramide phosphate*, Phenytoin sodium, Lidocaine hydrochloride, Tocainide hydrochloride, Mexiletine hydrochloride, Lorcainide hydrochloride, Amiodarone, Sotalol.

Anti-hyperlipidemic agents: Clofibrate, Lovastatin, Cholesteramine, and Cholestipol

Coagulant & Anticoagulants: Menadione, Acetomenadione, Warfarin*, Anisindione, clopidogrel

Drugs used in Congestive Heart Failure: Digoxin, Digitoxin, Nesiritide, Bosentan, Tezosentan.

UNIT IV

Drugs acting on Endocrine system: Nomenclature, Stereochemistry, and metabolism of steroids

Sex hormones: Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol.

Drugs for erectile dysfunction: Sildenafil, Tadalafil.

Oral contraceptives: Mifepristone, Norgestril, Levonorgestrol

Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone

Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole.

UNIT V

Antidiabetic agents: Insulin and its preparations

Sulfonyl ureas: Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride.

Biguanides: Metformin.

Thiazolidinediones: Pioglitazone, Rosiglitazone.

Meglitinides: Repaglinide, Nateglinide.

Glucosidase inhibitors: Acrabose, Voglibose.

Local Anesthetics: SAR of Local anesthetics

Benzoic Acid derivatives; Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine.

Amino Benzoic acid derivatives: Benzocaine, Butamben, Procaine, Butacaine, Propoxycaine, Tetracaine, Benoxinate.

Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine.

Miscellaneous: Phenacaine, Diperodon, Dibucaine.*

  1. Wilson and Giswold’s Organic medicinal and Pharmaceutical Chemistry.
  2. Foye’s Principles of Medicinal Chemistry.
  3. Burger’s Medicinal Chemistry, Vol I to IV.
  4. Introduction to principles of drug design- Smith and Williams.
  5. Remington’s Pharmaceutical Sciences.
  6. Martindale’s extra pharmacopoeia.
  7. Organic Chemistry by I.L. Finar, Vol. II.
  8. The Organic Chemistry of Drug Synthesis by Lednicer, Vol. 1to 5.
  9. Indian Pharmacopoeia.
  10. Text book of practical organic chemistry- A.I.Vogel.

Also read:

Semester V

Theory

BP501T Medicinal Chemistry II – Theory : Click here for Detailed syllabus
BP502T Industrial Pharmacy – Theory : Click here for Detailed syllabus
BP503T Pharmacology II – Theory : Click here for Detailed syllabus
BP504T Pharmacognosy II – Theory : Click here for Detailed syllabus
BP505T Pharmaceutical Jurisprudence – Theory : Click here for Detailed syllabus



Practical

BP506P Industrial Pharmacy I– Practical : Click here for Detailed syllabus
BP507P Pharmacology II – Practical : Click here for Detailed syllabus
BP508P Pharmacognosy II – Practical : Click here for Detailed syllabus