July 24, 2024

604T Biopharmaceutics and Pharmacokinetics Theory

Biopharmaceutics and Pharmacokinetics Theory

Unit I

Introduction to Biopharmaceutics

Absorption; Mechanisms of drug absorption through GIT, factors influencing drug absorption through GIT, absorption of the drug from Non per oral extra-vascular routes.

Distribution Tissue permeability of drugs, binding of drugs, apparent, the volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs

Unit II

Elimination: Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non-renal routes of drug excretion of drugs

Bioavailability and Bioequivalence: Definition and Objectives of bioavailability, absolute and relative bio-availability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.

Unit III

Pharmacokinetics: Definition and introduction to Pharmacokinetics, Compartment models, Non-compartment models, physiological models, One compartment open model. (a). Intravenous Injection (Bolus) (b). Intravenous infusion and (c) Extravascular administrations. Pharmacokinetics parameters – KE,t1/2,- Vd, AUC, Ka, Clt and CLR- definitions methods of eliminations, understanding of their significance and application

Unit IV

Multicompartment models: Two compartment open model. IV bolus Kinetics of multiple dosing, steady-state drug levels, calculation of loading and maintenance doses and their significance in clinical settings.

Unit V

Nonlinear Pharmacokinetics: a. Introduction, b. Factors causing Non-linearity. c. Michaelis-menton method of estimating parameters, Explanation with an example of drugs.


Recommended Books: (Latest Editions)

  1. Biopharmaceutics and Clinical Pharmacokinetics by, Milo Gibaldi.
  2. Biopharmaceutics and Pharmacokinetics; By Robert F Notari
  3. Applied biopharmaceutics and pharmacokinetics, Leon Shargel and Andrew B.C.YU 4th edition,Prentice-Hall Inernational edition.USA
  4. Bio pharmaceutics and Pharmacokinetics-A Treatise, By D. M. Brahmankar and Sunil B.Jaiswal,Vallabh Prakashan Pitampura, Delhi
  5. Pharmacokinetics: ByMilo Glbaldi Donald, R. Mercel Dekker Inc.
  6. Hand Book of Clinical Pharmacokinetics, ByMilo Gibaldi and Laurie Prescott by ADIS Health Science Press.
  7. Biopharmaceutics; By Swarbrick
  8. Clinical Pharmacokinetics, Concepts and Applications: ByMalcolm Rowland and
  9. Thomas, N. Tozen, Lea and Febrger, Philadelphia, 1995.
  10. Dissolution, Bioavailability and Bioequivalence, By Abdou H.M, Mack, Publishing Company, Pennsylvania 1989.
  11. Biopharmaceutics and Clinical Pharmacokinetics-An introduction 4th edition Revised and expanded by Rebort F Notari Marcel Dekker Inn, New York and Basel, 1987.
  12. Remington’s Pharmaceutical Sciences, ByMack Publishing Company, Pennsylvnia

Third Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

T Y B Pharm Sem VT Y B Pharm Sem VI
BP501T Medicinal Chemistry II TheoryBP601T Medicinal Chemistry III Theory
BP502T Industrial Pharmacy TheoryBP602T Pharmacology III Theory
BP503T Pharmacology II TheoryBP603T Herbal Drug Technology Theory
BP504T Pharmacognosy II TheoryBP604T Biopharmaceutics and Pharmacokinetics Theory
BP505T Pharmaceutical Jurisprudence TheoryBP605T Pharmaceutical Biotechnology – Theory
BP506P Industrial Pharmacy I PracticalBP606T Quality Assurance Theory
BP507P Pharmacology II PracticalBP607P Medicinal chemistry III Practical
BP508P Pharmacognosy II PracticalBP608P Pharmacology III Practical
BP609P Herbal Drug Technology Practical

Suggested readings

Recommended readings: