BP 204T Pathophysiology

BP 204T Pathophysiology Theory Syllabus

Unit I

Basic principles of Cell injury and Adaptation:

Introduction, definitions, Homeostasis, Components and Types of Feedback systems,

Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage)

Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),

Cell swelling, Intra cellular accumulation,

Calcification, Enzyme leakage and Cell Death Acidosis &Alkalosis,

Electrolyte imbalance

Basic mechanism involved in the process of inflammation and repair

Introduction, Clinical signs of inflammation, Different types of Inflammation,Mechanism of Inflammation – Alteration in vascular permeability and blood flow, migration of WBC’s,Mediators of inflammation,Basic principles of wound healing in the skin,Pathophysiology of Atherosclerosis

Unit II

Cardiovascular System:

Hypertension, congestive heart failure, ischemic heart disease (angina,myocardial infarction, atherosclerosis and arteriosclerosis)

Respiratory system

Asthma, Chronic obstructive airways diseases.

Renal system

Acute and chronic renal failure .

Unit III

Hematological Diseases

Iron deficiency, megaloblastic anemia (Vit B12 and folic acid), sickle cell anemia, thalasemia, hereditary acquired anemia, hemophilia

Endocrine system

Diabetes, thyroid diseases, disorders of sex hormones

Nervous system:

Epilepsy, Parkinson’s disease, stroke, psychiatric disorders: depression, schizophrenia and Alzheimer’s disease.

Gastrointestinal system:

Peptic Ulcer

Unit IV

Inflammatory bowel diseases, jaundice, hepatitis (A,B,C,D,E,F) alcoholic liver disease.

Disease of bones and joints:

Rheumatoid arthritis, osteoporosis and gout

Principles of cancer:

classification, etiology and pathogenesis of cancer

Diseases of bones and joints:

Rheumatoid Arthritis, Osteoporosis,Gout

Principles of Cancer:

Classification, etiology and pathogenesis of Cancer

Unit V

Infectious diseases

Meningitis,Typhoid, Leprosy, Tuberculosis Urinary tract infections

Sexually transmitted diseases

AIDS, Syphilis, Gonorrhea

1. Vinay Kumar, Abul K. Abas, Jon C. Aster; Robbins &Cotran Pathologic Basis of Disease; South Asia edition; India; Elsevier; 2014.

2. Harsh Mohan; Text book of Pathology; 6th edition; India; Jaypee Publications; 2010.

3. Laurence B, Bruce C, Bjorn K. ; Goodman Gilman’s The Pharmacological Basis of Therapeutics; 12 th edition; New York; McGraw-Hill; 2011.

4. Best, Charles Herbert 1899-1978; Taylor, Norman Burke 1885-1972; West, John B (John Burnard); Best and Taylor’s Physiological basis of medical practice; 12th ed; united states;

5. William and Wilkins, Baltimore;1991 [1990 printing].

6. Nicki R. Colledge, Brian R. Walker, Stuart H. Ralston;Davidson’s Principles and Practice of Medicine; 21st edition; London; ELBS/Churchill Livingstone; 2010.

7. Guyton A, John .E Hall; Textbook of Medical Physiology; 12 th edition; WB Saunders Company; 2010.

8. Joseph DiPiro, Robert L. Talbert, Gary Yee, Barbara Wells, L. Michael Posey; Pharmacotherapy: A Pathophysiological Approach; 9 th edition; London; McGraw-Hill Medical; 2014.

9. V. Kumar, R. S. Cotran and S. L. Robbins; Basic Pathology; 6 th edition; Philadelphia; WB Saunders Company; 1997.

10. Roger Walker, Clive Edwards; Clinical Pharmacy and Therapeutics; 3rd edition; London; Churchill Livingstone publication; 2003.

1. The Journal of Pathology. ISSN: 1096-9896 (Online)

2. The American Journal of Pathology. ISSN: 0002-9440

3. Pathology. 1465-3931 (Online)

4. International Journal of Physiology, Pathophysiology and Pharmacology. ISSN: 1944-8171 (Online)

5. Indian Journal of Pathology and Microbiology. ISSN-0377-4929.