Physical Pharmaceutics I Theory Syllabus

Physical Pharmaceutics I

UNIT-I Solubility of drugs

Introduction, Solubility expressions

Mechanisms of solute-solvent interactions

Ideal solubility parameters

Solvation & association

A quantitative approach to the factors influencing solubility of drugs (Video lecture link)

Diffusion principles in biological systems. (Video lecture link)

Solubility of gas in liquids (Video lecture link)

Solubility of liquids in liquids, (Binary solutions, ideal solutions) Raoult’s law, real solutions. (Video lecture link)

Partially miscible liquids, Critical solution temperature, and applications. (Video lecture link)

Distribution law, its limitations, and applications (Video lecture link)

UNIT-II States of Matter and properties of matter

State of matter, changes in the state of matter,
latent heats, vapor pressure, sublimation critical point, eutectic mixtures, gases, aerosols
– inhalers, relative humidity, liquid complexes, liquid crystals, glassy states, solid crystalline,
amorphous & polymorphism.
Physicochemical properties of drug molecules: Refractive index, optical rotation,
dielectric constant, dipole moment, dissociation constant, determinations and applications

UNIT-III Surface and interfacial phenomenon

Liquid interface, surface & interfacial tensions,
surface free energy, measurement of surface & interfacial tensions, spreading coefficient,
adsorption at liquid interfaces, surface

UNIT-IV Complexation and protein binding

Introduction, Classification of Complexation,
Applications, methods of analysis, protein binding, Complexation, and drug action,
crystalline structures of complexes and thermodynamic treatment of stability constants.

UNIT-V pH, buffers and Isotonic solutions

Sorensen’s pH scale, pH determination
(electrometric and calorimetric), applications of buffers, buffer equation, buffer capacity,
buffers in pharmaceutical and biological systems buffered isotonic solutions.

Physical Pharmaceutics I Recommended Books: (Latest Editions)

  1. Physical Pharmacy by Alfred Martin
  2. Experimental Pharmaceutics by Eugene, Parott.
  3. Tutorial Pharmacy by Cooper and Gunn.
  4. Stocklosam J. Pharmaceutical Calculations, Lea &Febiger, Philadelphia.
  5. Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to
    3, MarcelDekkar Inc.
  6. Liberman H.A, Lachman C, Pharmaceutical Dosage forms. Disperse
    systems, volume 1, 2, 3. Marcel Dekkar Inc.
  7. Physical Pharmaceutics by Ramasamy C and ManavalanR.
  8. LaboratoryManual of Physical Pharmaceutics, C.V.S. Subramanyam, J.
    Thimma settee
  9. Physical Pharmaceutics by C.V.S. Subramanyam
  10. Test book of Physical Phramacy, by Gaurav Jain & Roop K. Khar

Second Year B Pharm

Semester III


BP301T Pharmaceutical Organic Chemistry II – Theory : Click here for Detailed syllabus
BP302T Physical Pharmaceutics I –Theory : Click here for Detailed syllabus
BP303T Pharmaceutical Microbiology – Theory : Click here for Detailed syllabus
BP304T Pharmaceutical Engineering – Theory : Click here for Detailed syllabus


BP305P Pharmaceutical Organic Chemistry II – Practical : Click here for Detailed syllabus
BP306P Physical Pharmaceutics I – Practical : Click here for Detailed syllabus
BP307P Pharmaceutical Microbiology – Practical : Click here for Detailed syllabus
BP308P Pharmaceutical Engineering – Practical : Click here for Detailed syllabus