Problem in Pharmaceutical dosage form optimisation
Pharmaceutical dosage form optimization can be a complex and challenging process, with several potential problems that can arise. Some of these problems include:
- Formulation complexity: As mentioned earlier, developing a new drug formulation can involve evaluating a large number of variables, leading to a complex and high-dimensional design space.
- Limited experimental data: Conducting experiments to evaluate the properties and performance of different dosage forms can be time-consuming and expensive, resulting in limited experimental data.
- Nonlinear relationships between variables: The relationships between the different variables in a drug formulation can be highly nonlinear, making it difficult to predict the impact of changes to one variable on the overall performance of the formulation.
- Lack of robustness: Dosage forms may perform differently in different patients due to factors such as differences in gastrointestinal physiology or diet, making it difficult to develop a dosage form that is robust to individual variation.
- Regulatory constraints: The development of a new drug formulation must comply with regulatory guidelines and requirements, which can limit the design space and make it more difficult to optimize the formulation.
AI can help to address some of these problems by providing a more efficient and systematic approach to formulation design and optimization. However, the challenges of developing accurate and reliable AI models that can handle the complexity of drug formulation design remain.