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Determination of Melting point of organic compounds

Aim:

To determine the Melting point of a given solid sample.

Apparatus:

Glasswares:

Thiel’s tube, Thermometer, Thread/Rubberring, Capillary tube • Chemicals: Liquid paraffin (Note: If liquid paraffin is not available, melting point be determined by using concentrated sulphuric acid with caution.)

Theory:

 The Melting Point of the compound is the temperature at which the solid phase change to the liquid base. The high purity of the organic compound is indicated by a sharp melting point. Laboratory experiments for the determination of melting point will put light on the purity concept.

Procedure:

1. Take a capillary and seal it at one end, by holding it in flame for a while.

2. Take a small quantity (about 3-5mg) of the powdered organic compound into sealed

3. Tie the capillary tube containing the given sample of the organic compound to the thermometer near its bulb with the help of thread / rubberring.

4. Immerse the thermometer with a capillary tube into liquid paraffin taken in a Thiel’s tube. Care should be taken not to allow thread/rubber rings to come in contact with liquid paraffin.

5. Heat the Thiel’s tube slowly with the help of a gas burner.

6. The rate of heating should not be more than 3°C/min.

7. Note the temperature at which solid organic compound is converted to liquid and record it as the melting point of the given sample of an organic compound.

8. Repeat the procedure twice and take the observation.


F Y D Pharm & S Y D Pharm Notes, Books, Syllabus, PDF, Videos

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ER20-11T Pharmaceutics TheoryER20-21T Pharmacology Theory
ER20-11P Pharmaceutics PracticalER20-21P Pharmacology Practical
ER20-12T Pharmaceutical Chemistry TheoryER20-22T Community Pharmacy & Management Theory
ER20-12P Pharmaceutical Chemistry PracticalER20-22P Community Pharmacy & Management Practical
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ER20-26T Pharmacy Law & Ethics

Suggested readings:

  • Benzoic acid from benzamide synthesis: Pharmaceutical Chemistry Practical
  • Determination of Boiling point of organic compounds
  • BP208P Pharmaceutical Organic Chemistry I Practical
  • Simple Ointment Base Pharmaceutics Practical Lab Manual PDF
  • Conductometric titration of strong acid against a strong base

Recommended readings:

  • Pharmaceutics I Theory
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