Determination of sedimentation volume with the effect of different suspending agent
BP407P Physical Pharmaceutics II Practical
To determine the sedimentation volume with the effect of the different suspending agents.
Pharmaceutical suspension may be defined as a coarse dispersion in which insoluble solids are suspended in a liquid medium. It is also known as a heterogeneous system (or) more precisely biphasic system. The insoluble solids may have a size range from 10-10000µm and the liquid medium is normally water or a water-based vehicle.
Suspending agent is defined as a physiologically inert substance which increases the viscosity when added to suspensions. It helps in keeping the dispersed particles. Suspended thus there enhanced the physical stability and re-dispersion of the sediment or shaking.
Physical stability may be defined as a condition in which particles remain uniformly distributed throughout the dispersion with any signs of sedimentation.In practice, Physical stability may be defined as a condition in which particles should be easily re-suspended by a moderate shaking. If they settle suspensions when kept aside. The solids tend to settle at the bottom of the container due to gravitational pull on the particles of higher size. It is not possible to prevent the sedimentation volume and its case of re-dispersion is the common evaluation procedure for assessing the physical stability. The two sedimentation parameters are employed such as
- Sedimentation volume
- Degree of flocculation
• When a suspension is taken in a measuring cylinder volume and height is proportional and height can be conveniently measured through the term volume is included in the terminology sedimentation volume “F” is a dimension less number. The most pharmaceutical suspension has an “F” value of less than one. If f=1 the product has no sediment and no clear supernatant on standing which is an ideal condition. Normally “F” value lies between 0 and 1. Sometimes the network of flow is loose and fluffy and the ultimate volume of sediment increases. In this situation, the “F” value will be greater than one.
- Weigh 5gm of calcium carbonate and place in a mortar and add a small quantity of water and triturate the sample. After suspending the powder uniformly transfer the suspension into a 100ml measuring cylinder to make up the volume to 100ml with distilled water.
- Separately prepare 5% w/v of calcium carbonate suspension with 1% of a different suspending agent such as bentonite, and methylcellulose, respectively in a different vessel add a small quantity of water and triturate well. After the powder is uniformly suspended transfer the suspension into a separate 100ml measuring cylinder.
- Makeup the volume to 100ml with distilled water
- Shake the suspension simultaneously and kept aside
- Note the volume of sediment at time periods of 0,10,20,30,…60 minutes. Calculate the
- Draw the plot by taking “F” values on the “Y” axis and the time on the “X” axis.
5% calcium carbonate suspension and 1% carboxy methyl cellulose as suspending was found to be more physically stable compared with other suspending agents.
Physical Pharmaceutics II Practical
- Determination of particle size, and particle size distribution using the sieving method
- Determination of particle size, and particle size distribution using the Microscopic method
- Determination of bulk density, true density and porosity
- Determine the angle of repose and the influence of lubricant on the angle of repose
- Determination of viscosity of liquid using Ostwald’s viscometer
- Determination of sedimentation volume with the effect of different suspending agent
- Determination of sedimentation volume with the effect of different concentrations of single suspending agent
- Determination of viscosity of semisolid by using Brookfield viscometer
- Determination of reaction rate constant first order.
- Determination of reaction rate constant second order
- Accelerated stability studies
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