Determination of viscosity of semisolid by using Brookfield viscometer

Determination of viscosity of semisolid by using Brookfield viscometer

BP407P Physical Pharmaceutics II Practical

Aim:

To determine the viscosity of semisolid by using Brooke field viscometer

Principle:

Newton was the first to study the flow properties of liquids in quantitative terms liquids
that obey newton’s law of flow are called as Newtonian fluids

F= ɳG

Shear stress- shear rate

• The relationship is normally in the form of a curve rheogram or consistency curve. When data are plotted by taking “F” on the x-axis and “G” on the y-axis, a flow curve is obtained. The rheogram passes through the origin and the slope given the coefficient of viscosity system that follows this linear relationship are called Newtonian fluids. This class includes liquids such as water, glycerine, chloroform, solutions of syrups, and very dilute colloidal solutions. Simple liquids exhibit Newtonian flow. Rheological properties of heterogeneous dispersions such as emulsions, suspensions and semisolid are more complex and do not obey newton’s equation of flow based on the pattern of consistency curve, Non-Newtonian fluids are categorized as
• Plastic flow
• Pseudo plastic flow
• Dilatant flow

Procedure:

• Prepare bentonite magma (5%w/v), methylcellulose (2%w/v) and mineral oil. They show a Non-Newtonian rheological profile
• Measure the viscosity of these liquids using a Brookfield viscometer and observe the thixotropy phenomenon
• Place the spindle with the correct number listed in the data sheet in each liquid and rotate the spindle at the speeds indicated. Once the dial reading has stabilized, record the values of viscosity in (cps).

REPORT:

The viscosity of the given sample was found to be= centipoise (cps)

---

Physical Pharmaceutics II Practical

1. Determination of particle size, and particle size distribution using the sieving method
2. Determination of particle size, and particle size distribution using the Microscopic method
3. Determination of bulk density, true density and porosity
4. Determine the angle of repose and the influence of lubricant on the angle of repose
5. Determination of viscosity of liquid using Ostwald’s viscometer
6. Determination of sedimentation volume with the effect of different suspending agent
7. Determination of sedimentation volume with the effect of different concentrations of single suspending agent
8. Determination of viscosity of semisolid by using Brookfield viscometer
9. Determination of reaction rate constant first order.
10. Determination of reaction rate constant second order
11. Accelerated stability studies

---

Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

S Y B Pharm Sem III	S Y B Pharm Sem IV
BP301T Pharmaceutical Organic Chemistry II Theory	BP401T Pharmaceutical Organic Chemistry III Theory
BP302T Physical Pharmaceutics I Theory	BP402T Medicinal Chemistry I Theory
BP303T Pharmaceutical Microbiology Theo	BP403T Physical Pharmaceutics II Theory
BP304T Pharmaceutical Engineering Theory	BP404T Pharmacology I Theory
BP305P Pharmaceutical Organic Chemistry II Practical	BP405T Pharmacognosy I Theory
BP306P Physical Pharmaceutics I Practical	BP406P Medicinal Chemistry I Practical
BP307P Pharmaceutical Microbiology Practical	BP407P Physical Pharmaceutics II Practical
BP308P Pharmaceutical Engineering Practical	BP408P Pharmacology I Practical
	BP409P Pharmacognosy I Practical

---

Suggested readings

• Determination of viscosity of liquid using Ostwald’s viscometer
• Creams: Types, Advantages, Disadvantages, Pharmaceutics Notes PDF
• Least Square Method: Curve fitting, fitting the lines
• BP407P Physical Pharmaceutics II Practical
• BP306P Physical Pharmaceutics I Practical

Recommended readings

• Pharmaceutics I Theory

---