3.1 Pharmacology II Pharm D Syllabus, Notes, PDF, Books, MCQ, Downloads
1. Pharmacology of Drugs acting on Blood and blood-forming agents
b) Thrombolytics and antiplatelet agents
c) Haemopoietics and plasma expanders
2. Pharmacology of drugs acting on the Renal System
b) Sulfonamides and co-trimoxazole
c) Penicillins and Cephalosporins
d) Tetracycline and Chloramphenicol
e) Macrolides, Aminoglycosides, Polyene & Polypeptide antibiotics
f) Quinolines and Fluroquinolines
g) Antifungal antibiotics
h) Antiviral agents
i) Chemotherapy of tuberculosis and leprosy
j) Chemotherapy of Malaria
k) Chemotherapy of protozoal infections (amoebiasis, Giardiasis)
l) Pharmacology of Anthelmintic drugs
m) Chemotherapy of cancer (Neoplasms)
Pharmacology of immunosuppressants and stimulants
5. Principles of Animal toxicology
Acute, sub-acute and chronic toxicity
6. The dynamic cell
The structures and functions of the components of the cell
a) Cell and macromolecules: Cellular classification, subcellular organelles, macromolecules, large macromolecular assemblies
b) Chromosome structure: Pro and eukaryotic chromosome structures, chromatin structure, genome complexity, and the flow of genetic information.
c) DNA replication: General, bacterial and eukaryotic DNA replication.
d) The cell cycle: Restriction point, cell cycle regulators and modifiers.
e) Cell signalling: Communication between cells and their environment, ion channels, signal transduction pathways (MAP kinase, P38 kinase, JNK, Ras and PI3-kinase pathways, biosensors.
The Gene: Genome structure and function:
a) Gene structure: Organization and elucidation of genetic code.
b) Gene expression: Expression systems (pro and eukaryotic), genetic elements that control gene expression (nucleosomes, histones, acetylation, HDACS, DNA binding protein families.
c) Transcription and Transcription factors: Basic principles of transcription in pro and eukaryotes. Transcription factors that regulate transcription in pro and eukaryotes.
RNA processing: rRNA, tRNA and mRNA processing.
Protein synthesis: Mechanisms of protein synthesis, initiation in eukaryotes, translation control and post-translation events
Altered gene functions: Mutations, deletions, amplifications, LOH, traslocations, trinucleotide repeats and other genetic abnormalities. Oncogenes and tumour suppressor genes.
The gene sequencing, mapping and cloning of human disease genes. Introduction to gene therapy and targeting.
Recombinant DNA technology: principles. Processes (gene transfer technology) and applications
Pharmacology II Practicals
- Study of laboratory animals and their handling (a. Frogs, b. Mice, c. Rats, d. Guinea pigs, e. Rabbits).
- Study of physiological salt solutions used in experimental pharmacology.
- Study of laboratory appliances used in experimental pharmacology.
- Study of the use of anaesthetics in laboratory animals.
- To record the dose-response curve of Ach using isolated ileum/rectus abdominis muscle preparation.
- To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by interpolation method.
- To carry out bioassay of Ach using isolated ileum/rectus abdominis muscle preparation by a three-point method.
- To record the dose-response curve of Histamine using isolated guinea-pig ileum preparation.
- Study of agonistic and antagonistic effects of drugs using isolated guinea-pig ileum preparation.
- To carry out bioassay of Histamine using isolated guinea-pig ileum preparation by interpolation method.
- To carry out bioassay of Histamine using guinea-pig ileum preparation by a three-point method.
- To study the routes of administration of drugs in animals (Rats, Mice, Rabbits).
- Study of theory, principle, the procedure involved and interpretation of given results for the following experiments:
a) Analgesic property of drug using analgesiometer.
b) Antiinflammatory effect of drugs using rat-paw edema method.
c) Anticonvulsant activity of drugs using maximal electroshock and pentylene tetrazole methods.
d) Antidepressant activity of drugs using pole climbing apparatus and pentobarbitone-induced sleeping time methods.
e) Locomotor activity evaluation of drugs using actophotometer and rotarod.
f) Cardiotonic activity of drugs using isolated frog heart and mammalian heart preparations.
Third Year Pharm D Subjects
Roll on deodrant base ingredients
Use Aartificial Intelligence for optimisation of pharmaceutical formulation
Bayesian approch for optimisation of pharmaceutical formulation