Determine the angle of repose and the influence of lubricant on the angle of repose
BP407P Physical Pharmaceutics II Practical
AIM
To determine the effect of glidants on lubricants of angle of repose
REQUIREMENTS
Lactose powder
Starch paste
Talc
Mortar and pestle
Funnel, stand
PRINCIPLE
Lubricants are glidants of friction during tablet, ejection between the starch of the tablet and the walls of the die cavity. The most widely used lubricants have been steric acid and steric acid derivatives such as calcium and magnesium stearate and talc. Glidants are intended to produce flow of the tablet granulation of powder materials by reducing friction between the particles. The most widely used glidants have been derivation of talc and corn starch.
PROCEDURE
Select a glass funnel which has a round shape of 15-30mm of diameter with flat edge
Fix the funnel with a clamp (on the ring)
Place the glass plate on the ring and arrange it below the glass funnel
Keep on graph paper on the glass funnel
Weigh approximately 100gm of granules
Pour the granules while blocking the orifice of the funnel be thumb
Remove the thumb the granules load at flow down into the graph paper and form a cone shaped
Adjust the thumb the funnel clamp so that the gap between the bottom of the funnel peak of the powder pile is about 3mm
Repeat the 5-7 steps and approximate graph is maintained
Finally pour the granules back into funnel and allow to flow
Mark four points which are opposite to each other on the circular base on the graph paper
Record the readings in table, this value is the diameter calculate the radius in ®
Measure the height of the pile using two rulers
Keep one ruler vertically and another horizontally to touch the peak of the pile, then read the value for the vertical scale.
Substitutes the value in equation to obtained the angle of repose, generally the (h/r) measure is the angle of repose data were plotted semi-long paper and copies of curves made available for the purpose of calculating angle
Repeat the procedure 2 more time and take on average
REPORT
The angle of repose of the given granules (without glidant) = 22º 93’
The concentration is 2%
The effect of glidants of lubricants of angle of repose is = 22º69’
Inference is that the flow of granules “Excellent”

Physical Pharmaceutics II Practical
- Determination of particle size, and particle size distribution using the sieving method
- Determination of particle size, and particle size distribution using the Microscopic method
- Determination of bulk density, true density and porosity
- Determine the angle of repose and the influence of lubricant on the angle of repose
- Determination of viscosity of liquid using Ostwald’s viscometer
- Determination of sedimentation volume with the effect of different suspending agent
- Determination of sedimentation volume with the effect of different concentrations of single suspending agent
- Determination of viscosity of semisolid by using Brookfield viscometer
- Determination of reaction rate constant first order.
- Determination of reaction rate constant second order
- Accelerated stability studies
Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
Suggested readings
Recommended readings:
Pertussis Vaccine: Why It’s Essential for Preventing Whooping Cough
Subacute Sclerosing Panencephalitis (SSPE): Causes, Symptoms, and Treatment
Trump Halts HIV Drug Distribution to Poor Countries: What It Means for Global Health