July 20, 2024

Determine the angle of repose and the influence of lubricant on the angle of repose

Determine the angle of repose and the influence of lubricant on the angle of repose

BP407P Physical Pharmaceutics II Practical

AIM
To determine the effect of glidants on lubricants of angle of repose

REQUIREMENTS
 Lactose powder
 Starch paste
 Talc
 Mortar and pestle
 Funnel, stand

PRINCIPLE
Lubricants are glidants of friction during tablet, ejection between the starch of the tablet and the walls of the die cavity. The most widely used lubricants have been steric acid and steric acid derivatives such as calcium and magnesium stearate and talc. Glidants are intended to produce flow of the tablet granulation of powder materials by reducing friction between the particles. The most widely used glidants have been derivation of talc and corn starch.

PROCEDURE
 Select a glass funnel which has a round shape of 15-30mm of diameter with flat edge
 Fix the funnel with a clamp (on the ring)
 Place the glass plate on the ring and arrange it below the glass funnel
 Keep on graph paper on the glass funnel
 Weigh approximately 100gm of granules
 Pour the granules while blocking the orifice of the funnel be thumb
 Remove the thumb the granules load at flow down into the graph paper and form a cone shaped
 Adjust the thumb the funnel clamp so that the gap between the bottom of the funnel peak of the powder pile is about 3mm
 Repeat the 5-7 steps and approximate graph is maintained
 Finally pour the granules back into funnel and allow to flow
 Mark four points which are opposite to each other on the circular base on the graph paper
 Record the readings in table, this value is the diameter calculate the radius in ®
 Measure the height of the pile using two rulers
 Keep one ruler vertically and another horizontally to touch the peak of the pile, then read the value for the vertical scale.
 Substitutes the value in equation to obtained the angle of repose, generally the (h/r) measure is the angle of repose data were plotted semi-long paper and copies of curves made available for the purpose of calculating angle
 Repeat the procedure 2 more time and take on average

REPORT
The angle of repose of the given granules (without glidant) = 22º 93’
The concentration is 2%
The effect of glidants of lubricants of angle of repose is = 22º69’
Inference is that the flow of granules “Excellent”


Physical Pharmaceutics II Practical

  1. Determination of particle size, and particle size distribution using the sieving method
  2. Determination of particle size, and particle size distribution using the Microscopic method
  3. Determination of bulk density, true density and porosity
  4. Determine the angle of repose and the influence of lubricant on the angle of repose
  5. Determination of viscosity of liquid using Ostwald’s viscometer
  6. Determination of sedimentation volume with the effect of different suspending agent
  7. Determination of sedimentation volume with the effect of different concentrations of single suspending agent
  8. Determination of viscosity of semisolid by using Brookfield viscometer
  9. Determination of reaction rate constant first order.
  10. Determination of reaction rate constant second order
  11. Accelerated stability studies

Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

S Y B Pharm Sem IIIS Y B Pharm Sem IV
BP301T Pharmaceutical Organic Chemistry II TheoryBP401T Pharmaceutical Organic Chemistry III Theory
BP302T Physical Pharmaceutics I TheoryBP402T Medicinal Chemistry I Theory
BP303T Pharmaceutical Microbiology TheoBP403T Physical Pharmaceutics II Theory
BP304T Pharmaceutical Engineering TheoryBP404T Pharmacology I Theory
BP305P Pharmaceutical Organic Chemistry II PracticalBP405T Pharmacognosy I Theory
BP306P Physical Pharmaceutics I PracticalBP406P Medicinal Chemistry I Practical
BP307P Pharmaceutical Microbiology PracticalBP407P Physical Pharmaceutics II Practical
BP308P Pharmaceutical Engineering PracticalBP408P Pharmacology I Practical
BP409P Pharmacognosy I Practical

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