February 23, 2024

Determination of reaction rate constant first order

Determination of reaction rate constant first order

BP407P Physical Pharmaceutics II Practical

AIM:

To determine the reactant rate constant and half-life and the ester (methyl acetate or number of globules) at 0.5M HCL at room temperature.

APPARATUS AND CHEMICALS REQUIRED:
 Conical flask (250 ml)
 10 ml volumetric pipette
 Burette
 Ethyl acetate or methyl acetate
 Test tube
 0.5 N HCL solution
 0.25 N NAOH solution
 Phenolphthalein indicator
 Ice cold water

PROCEDURE:

Preparation of hydrochloric acid solution (0.5N) IP:

Solutions of any normality XN may be prepared by diluting 85 x ml of HCL to 1000ml with water. Measure 850 ml of distilled water into a 1000ml volumetric flask. Add 42.5 ml of conc.HCL and slowly added. Finally make up the water in 1000ml.

Preparation of NAOH solution (0.25 N) IP:

Solutions of any normally XN may be prepared by dissolving 40 x gm of NAOH in water and diluting to 1000ml. weigh 10gm of NAOH and transferd into 1000ml volumetric flask. Add water slowly with stirring finally makeup the water into 1000ml.

PROCEDURE: KINETIC METHOD

 100ml of 0.5N HCL solution is measured and transferred into a 250ml conical flask
 It should be kept in the water bath for equilibrium (do not heat)
 10ml of the given ester it transfer into the test tube and kept in the water bath for equilibrium. Normally it takes 10minutes
 The acid solution its mix ester sample thoroughly and kept in water bath
 Immediately after mixing 5ml of the mixer is withdrawn using the pipette and transferred in to a conical flask containing 10ml ice water (0 time)
 The few drops of phenolphthalein indicator is added to the mixture
 The reaction mixer is titrated against 0.25N NAOH solution. This value of alkali consumed represents V0.
 5ml samples by periodically at 10, 20, 30, 40, 50, 60, 75minutes. the volume consumed at each time interval represent Vt
 The reaction mixture is heated at water bath at the 600c at 20 minutes
 The mixture cooled to room temperature
 5ml of sample by withdrawn at transfer into the conical flask containing 10 ml ice cold water. The titration is repeated and this value represents Vα.

REPORT:

The reaction rate constant (k) of the given data (methyl acetate or ethyl acetate) in 0.5N HCL acid is
From graphical method= minutes From substitution method= minutes
The half -life (t1/2) of the given ester (methyl acetate or ethyl acetate) in 0.5N HCL acid is From graphical method=
From substitution method=


Physical Pharmaceutics II Practical

  1. Determination of particle size, and particle size distribution using the sieving method
  2. Determination of particle size, and particle size distribution using the Microscopic method
  3. Determination of bulk density, true density and porosity
  4. Determine the angle of repose and the influence of lubricant on the angle of repose
  5. Determination of viscosity of liquid using Ostwald’s viscometer
  6. Determination of sedimentation volume with the effect of different suspending agent
  7. Determination of sedimentation volume with the effect of different concentrations of single suspending agent
  8. Determination of viscosity of semisolid by using Brookfield viscometer
  9. Determination of reaction rate constant first order.
  10. Determination of reaction rate constant second order
  11. Accelerated stability studies

Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

S Y B Pharm Sem IIIS Y B Pharm Sem IV
BP301T Pharmaceutical Organic Chemistry II TheoryBP401T Pharmaceutical Organic Chemistry III Theory
BP302T Physical Pharmaceutics I TheoryBP402T Medicinal Chemistry I Theory
BP303T Pharmaceutical Microbiology TheoBP403T Physical Pharmaceutics II Theory
BP304T Pharmaceutical Engineering TheoryBP404T Pharmacology I Theory
BP305P Pharmaceutical Organic Chemistry II PracticalBP405T Pharmacognosy I Theory
BP306P Physical Pharmaceutics I PracticalBP406P Medicinal Chemistry I Practical
BP307P Pharmaceutical Microbiology PracticalBP407P Physical Pharmaceutics II Practical
BP308P Pharmaceutical Engineering PracticalBP408P Pharmacology I Practical
BP409P Pharmacognosy I Practical

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