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Determination of bulk density, true density and porosity

BP407P Physical Pharmaceutics II Practical

Aim:

To determine the bulk density, true density and percentage porosity of the given granules

Principle:

• When particles are packed loosely lots of gaps between the particles are
observed. Hence the bulk volume increases by making the powder light based on bulk volume powder are classified as light and heavy
• light powder have high bulk volumes on the other hand smaller particles the powder assume low bulk volume or high bulk volume density such powder are called heavy powder. The bulk density depends on particle size distribution, shape, and cohesiveness of particles.
• True density is the density of the powder itself True density= ⁄
• The density depend on the type of atom in a molecular rearrangement of atoms in a molecule and arrangement of molecule in the sample volume occupied by voids and the intra particle pores are not included in the most common method used in the determination of true density or gas displacement or liquid displacement method.
• This method is used to select a solvent in which the powder is insoluble

Procedure:

Approximately 20gm of powder is transformed to a 500ml cylinder and tap mechanically or by tapping device until a constant volume is obtained thus volume is bulk volume and the void space among powder particle

True density:

Determination of true density of the material by solvent displacement method

  • Weigh accurately a clean and dry density bottle
  • Take the weight of density bottle with small quantity of powder sample
  • Now fill the density bottle by solvent without removing the powder material
  • Calculate the true density of given powder sample

Determination of percentage porosity

Porosity is defined as the void volume to the bulk volume of the granules
Porosity=1- ⁄

Report

  • The bulk density of the given sample of granules was found to be = g/cm3
  • The true density of a given powder was found to be = g/cm3
  • The percentage porosity of the a given powder is = %

Physical Pharmaceutics II Practical

  1. Determination of particle size, and particle size distribution using the sieving method
  2. Determination of particle size, and particle size distribution using the Microscopic method
  3. Determination of bulk density, true density and porosity
  4. Determine the angle of repose and the influence of lubricant on the angle of repose
  5. Determination of viscosity of liquid using Ostwald’s viscometer
  6. Determination of sedimentation volume with the effect of different suspending agent
  7. Determination of sedimentation volume with the effect of different concentrations of single suspending agent
  8. Determination of viscosity of semisolid by using Brookfield viscometer
  9. Determination of reaction rate constant first order.
  10. Determination of reaction rate constant second order
  11. Accelerated stability studies

Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

S Y B Pharm Sem IIIS Y B Pharm Sem IV
BP301T Pharmaceutical Organic Chemistry II TheoryBP401T Pharmaceutical Organic Chemistry III Theory
BP302T Physical Pharmaceutics I TheoryBP402T Medicinal Chemistry I Theory
BP303T Pharmaceutical Microbiology TheoBP403T Physical Pharmaceutics II Theory
BP304T Pharmaceutical Engineering TheoryBP404T Pharmacology I Theory
BP305P Pharmaceutical Organic Chemistry II Practical BP405T Pharmacognosy I Theory
BP306P Physical Pharmaceutics I PracticalBP406P Medicinal Chemistry I Practical
BP307P Pharmaceutical Microbiology PracticalBP407P Physical Pharmaceutics II Practical
BP308P Pharmaceutical Engineering PracticalBP408P Pharmacology I Practical
BP409P Pharmacognosy I Practical

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