BP605T Pharmaceutical Biotechnology Theory Books, PDF Notes, Download
Table of contents
Unit 1 Introduction, Enzyme technology, Protein engineering
a) Brief introduction to Biotechnology with reference to Pharmaceutical Sciences.
b) Enzyme Biotechnology- Methods of enzyme immobilization and applications.
c) Biosensors- Working and applications of biosensors in Pharmaceutical Industries.
d) Brief introduction to Protein Engineering.
e) Use of microbes in industry. Production of Enzymes- Amylase, Catalase, Peroxidase, Lipase, Protease, Penicillinase.
f) Basic principles of genetic engineering.
Unit 2 rDNA, PCR
a) Study of
b) Recombinant DNA technology. Application of genetic engineering in medicine.
c) Application of rDNA technology and genetic engineering in the production of
- Interferon,
- Vaccines hepatitis B,
- Hormones Insulin
Unit 3 Immunology
Types of immunity– humoral immunity, cellular immunity
a) Structure of Immunoglobulins
b) Structure and Function of MHC
c) Hypersensitivity reactions, Immune stimulation, and Immune suppressions.
d) General method of the preparation of bacterial vaccines, toxoids, viral vaccines, antitoxins, serum-immune blood derivatives, and other products relative to immunity.
e) Storage conditions and stability of official vaccines
f) Hybridoma technology- Production, Purification and Applications
g) Blood products and Plasma Substitutes.
Unit 4 Immunoblotting, Biotransformation, Mutation
a) Immunoblotting techniques- ELISA, Western blotting, Southern blotting.
b) Genetic organization of Eukaryotes and Prokaryotes
c) Microbial genetics including transformation, transduction, conjugation, plasmids, and transposons.
d) Introduction to Microbial biotransformation and applications.
e) Mutation: Types of mutation/mutants.
Unit 5 Fermentation, Blood Products
a) Fermentation methods and general requirements, the study of media, equipment, sterilization methods, aeration process, stirring.
b) Large-scale production fermenter design and its various controls.
c) Study of the production of – Penicillins, Citric acid, Vitamin B12, Glutamic acid, Griseofulvin
d) Blood Products: Collection, Processing, and Storage of whole human blood, dried
human plasma, plasma Substitutes.
Pharmaceutical Biotechnology Recommended Books (Latest edition):
- B.R. Glick and J.J. Pasternak: Molecular Biotechnology: Principles and Applications of RecombinantDNA: ASM Press Washington D.C.
- RA Goldshy et. al., : Kuby Immunology.
- J.W. Goding: Monoclonal Antibodies.
- J.M. Walker and E.B. Gingold: Molecular Biology and Biotechnology by Royal Society of Chemistry.
- Zaborsky: Immobilized Enzymes, CRC Press, Degraland, Ohio.
- S.B. Primrose: Molecular Biotechnology (Second Edition) Blackwell Scientific Publication.
- Stanbury F., P., Whitakar A., and Hall J., S., Principles of fermentation technology, 2nd edition, Aditya books Ltd., New Delhi
Reference:
SIMPLIFIED CONCEPTS OF BIOTECHNOLOGY By, Dr. Pramod Kadu & Ms. Suchita Vishwakarma
Third Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
Suggested readings:
Also read:
- Pharmaceutics I Practical
- Social Pharmacy Theory
- Industrial pharmacy
- Pharmacology II
- Computer Applications in Pharmacy Practical
- Pathophysiology
