Pharmaceutical Organic Chemistry II Syllabus
Pharmaceutical Organic Chemistry II
UNIT I Benzene and its derivatives
A. Analytical, synthetic and other evidence in the derivation of the structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule
B. Reactions of benzene – nitration, sulphonation, halogenation reactivity, Friedelcrafts alkylation- reactivity, limitations,
Friedel crafts acylation.
C. Substituents, the effect of substituents on reactivity and orientation of monosubstituted benzene compounds towards electrophilic substitution reaction
D. Structure and uses of DDT, Saccharin, BHC, and Chloramine
UNIT II Phenols
Acidity of phenols, the effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols
Aromatic Amines
Basicity of amines, the effect of substituents on basicity, and synthetic uses of aryl diazonium salts
Aromatic Acids* –Acidity, the effect of substituents on acidity, and important reactions of benzoic acid.
UNIT III Fats and Oils
a. Fatty acids – reactions.
b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
c. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and the principle involved in their determination.
UNIT IV Polynuclear hydrocarbons:
a. Synthesis, reactions
b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives
UNIT V Cyclo alkanes
Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only
Pharmaceutical Organic Chemistry II Recommended Books (Latest Editions)
- Organic Chemistry byMorrison and Boyd
- Organic Chemistry by I.L. Finar , Volume-I
- Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.
- Organic Chemistry by P.L.Soni
- Practical Organic Chemistry byMann and Saunders.
- Vogel’s text book of Practical Organic Chemistry
- Advanced Practical organic chemistry by N.K.Vishnoi.
Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
Suggested readings:
Pharmaceutics I Practical * Social Pharmacy Theory * Pharmaceutical Biotechnology Theory * Medicinal Chemistry II * Pharmacology II * Pharmaceutical Analysis I Theory * heterocyclic compounds nomenclature video * Pathophysiology * Pharmaceutics I Theory *
