Methods of preparations of suppositories
Suppositories are solid dosage forms that are intended for rectal or vaginal administration. They are used to deliver drugs that are poorly absorbed through oral administration, have a bitter taste, or are not suitable for oral administration. The following are the methods of preparation of suppositories:
- Molding: In this method, the suppository base is melted, and the drug is added to it. The mixture is then poured into molds, allowed to cool and solidify, and then removed from the molds. Molding is a simple and inexpensive method of preparing suppositories.
- Compression: In this method, the drug is mixed with a suppository base, and the mixture is compressed into a suppository shape using a tablet press. Compression is a fast and efficient method of preparing suppositories.
- Hand rolling: This method is typically used for preparing small batches of suppositories. The drug and the suppository base are mixed, and the mixture is rolled by hand into the desired shape.
- Fused deposit: In this method, the suppository base and the drug are melted together, and the mixture is poured into a mold. The mold is then rotated to evenly distribute the mixture, and then cooled to solidify the suppositories.
- Suppository molding machine: This method involves the use of a specialized machine that automatically melts the suppository base and drug, mixes them, and dispenses the mixture into molds. The machine is capable of producing large quantities of suppositories efficiently and accurately.
The method used for preparing suppositories depends on the nature of the drug and the desired physical characteristics of the suppository.
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