February 22, 2024

Formation of haemoglobin

Formation of haemoglobin

Hemoglobin is a protein found in red blood cells that is responsible for carrying oxygen from the lungs to the body’s tissues. The process of hemoglobin formation is called erythropoiesis and involves several steps:

Step 1:

Stem cells in the bone marrow differentiate into immature red blood cells, called erythroblasts.

Step 2:

Erythroblasts start to synthesize hemoglobin. Hemoglobin is made up of four protein chains called globins, and each globin chain is associated with a heme group that contains an iron atom.

Step 3:

The synthesis of hemoglobin requires a supply of iron, which is obtained from the diet and stored in the body. Iron is transported to the bone marrow, where it is incorporated into the heme groups of the globin chains.

Step 4:

The globin chains and heme groups are then assembled into hemoglobin molecules.

Step 5:

The erythroblasts mature into reticulocytes, which still contain some ribosomal RNA.

Step 6:

The reticulocytes are released from the bone marrow into the bloodstream, where they lose their ribosomal RNA and mature into fully functional red blood cells.

Overall, the formation of hemoglobin is a complex process that requires the coordinated synthesis of several different components, including protein chains, heme groups, and iron. Any disruption in this process can lead to abnormalities in red blood cell production or function, which can result in anemia and other blood disorders.

Frequently Asked Questions (FAQ)

What is hemoglobin?

Hemoglobin is a protein molecule found in red blood cells that plays a crucial role in transporting oxygen from the lungs to various tissues and organs in the body.

How is hemoglobin formed?

The formation of hemoglobin involves a complex process known as erythropoiesis, which occurs in the bone marrow. Here are the key steps:
Stem cells: Hematopoietic stem cells in the bone marrow differentiate into erythrocyte (red blood cell) precursors.
Proerythroblast stage: The stem cells develop into proerythroblasts, which undergo several divisions.
Erythroblast stage: Proerythroblasts transform into erythroblasts. During this stage, the cells accumulate hemoglobin and become more specialized for oxygen transport.
Reticulocyte stage: Erythroblasts continue to mature, and the nucleus is expelled from the cell, forming reticulocytes. These reticulocytes still contain remnants of ribosomes.
Mature red blood cells: Reticulocytes further mature into fully functional red blood cells. They lose their remaining ribosomes and other organelles, leaving them with a biconcave shape and ample space to carry hemoglobin.

What is the role of iron in hemoglobin formation?

Iron is an essential component for the formation of hemoglobin. It binds to the heme groups within the hemoglobin molecule, allowing oxygen to bind to the iron atom. Without iron, the hemoglobin molecule cannot effectively transport oxygen.

Are there any other components required for hemoglobin formation?

Yes, apart from iron, other essential components required for hemoglobin formation include amino acids, specifically glycine and other building blocks for the globin protein chains, as well as vitamins and minerals like vitamin B12, folate, and copper.

What happens if there is a deficiency or abnormality in hemoglobin formation?

Deficiencies or abnormalities in hemoglobin formation can lead to various disorders, such as anemia, thalassemia, and sickle cell disease. These conditions can impair the oxygen-carrying capacity of red blood cells, resulting in symptoms like fatigue, weakness, and compromised tissue oxygenation.

How long does the process of hemoglobin formation take?

The entire process of hemoglobin formation, from stem cells to mature red blood cells, typically takes around 7-10 days.

Can diet affect hemoglobin formation?

Yes, a well-balanced diet that includes iron-rich foods (such as red meat, leafy greens, legumes) and other nutrients involved in hemoglobin synthesis (such as vitamin C, vitamin B12, and folic acid) can support healthy hemoglobin formation. Adequate nutrition is essential for the production of healthy red blood cells.

MCQ Formation of haemoglobin

  1. Which of the following is the primary site for the formation of hemoglobin?
    a) Liver
    b) Spleen
    c) Bone marrow
    d) Lungs
  2. What is the main precursor molecule involved in the formation of hemoglobin?
    a) Bilirubin
    b) Heme
    c) Iron
    d) Protoporphyrin
  3. Where does the incorporation of iron into protoporphyrin occur during hemoglobin synthesis?
    a) Cytoplasm
    b) Nucleus
    c) Mitochondria
    d) Golgi apparatus
  4. Which of the following is responsible for the red color of hemoglobin?
    a) Iron
    b) Oxygen
    c) Carbon dioxide
    d) Bilirubin
  5. What is the role of erythropoietin in hemoglobin formation?
    a) It transports oxygen in the blood.
    b) It regulates the production of red blood cells.
    c) It binds to iron and forms heme.
    d) It breaks down old red blood cells.
  6. Which globin chains are present in adult hemoglobin?
    a) Alpha and beta
    b) Alpha and gamma
    c) Alpha and delta
    d) Alpha and epsilon
  7. Where does the final assembly of globin chains and heme occur to form hemoglobin?
    a) Cytoplasm
    b) Nucleus
    c) Ribosomes
    d) Endoplasmic reticulum
  8. Which of the following conditions can result from a deficiency in hemoglobin production?
    a) Anemia
    b) Hemochromatosis
    c) Polycythemia
    d) Sickle cell disease


  1. c) Bone marrow
  2. d) Protoporphyrin
  3. c) Mitochondria
  4. a) Iron
  5. b) It regulates the production of red blood cells.
  6. a) Alpha and beta
  7. c) Ribosomes
  8. a) Anemia

First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

F Y B Pharm Sem-IF Y B Pharm Sem-II
BP101T Human Anatomy and Physiology I TheoryBP201T Human Anatomy and Physiology II – Theory
BP102T Pharmaceutical Analysis I TheoryBP202T Pharmaceutical Organic Chemistry I Theory
BP103T Pharmaceutics I TheoryBP203T Biochemistry – Theory
BP104T Pharmaceutical Inorganic Chemistry TheoryBP204T Pathophysiology – Theory
BP105T Communication skills TheoryBP205T Computer Applications in Pharmacy Theory
BP106RBT Remedial BiologyBP206T Environmental sciences – Theory
BP106RMT Remedial Mathematics TheoryBP207P Human Anatomy and Physiology II Practical
BP107P Human Anatomy and Physiology PracticalBP208P Pharmaceutical Organic Chemistry I Practical
BP108P Pharmaceutical Analysis I PracticalBP209P Biochemistry Practical
BP109P Pharmaceutics I PracticalBP210P Computer Applications in Pharmacy Practical
BP110P Pharmaceutical Inorganic Chemistry Practical
BP111P Communication skills Practical
BP112RBP Remedial Biology Practical

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