Table of contents
BP203T Biochemistry Theory
UNIT I Biomolecules, Bioenergetics
Biomolecules
Introduction, classification, chemical nature and biological role of carbohydrate, lipids, nucleic acids, amino acids and proteins.
Bioenergetics
Concept of free energy, endergonic and exergonic reaction,
Relationship between free energy, enthalpy and entropy;
Redox potential. Energy-rich compounds;
classification; biological significances of ATP and cyclic AMP
UNIT II Carbohydrate metabolism, Biological oxidation
Metabolism, Anabolism, Catabolism : https://youtu.be/hkvTXA94ns4
Carbohydrate metabolism
Glycolysis – Pathway, energetics and significance
Citric acid cycle- Pathway, energetics and significance
HMP shunt and its significance; Glucose-6-Phosphate dehydrogenase (G6PD) deficiency
Glycogen metabolism Pathways and glycogen storage diseases (GSD)
Gluconeogenesis- Pathway and its significance
Hormonal regulation of blood glucose level and Diabetes mellitus
Metabolism of Carbohydrates :
Glycolysis Introduction and Significance: https://youtu.be/z5wYDUJbmaY
Glycolysis, EM Pathway, MEP Pathway: https://youtu.be/VFzMwTWj-yg
MCQ Carbohydrate metabolism :
Part 1: https://youtu.be/5FwwmgJAUac
Part 2: https://youtu.be/WQ9X3slCcUs
Part 3: https://youtu.be/V-c8dJm0ksc
Part 4: https://youtu.be/rgkVBtYhq14
Biological oxidation
Electron transport chain (ETC) and its mechanism.Oxidative phosphorylation & its mechanism and substrate phosphorylation
Inhibitors ETC and oxidative phosphorylation/Uncouplers level
UNIT III Lipid metabolism, Amino acid metabolism
Lipid metabolism
β-Oxidation of saturated fatty acid (Palmitic acid)
Formation and utilization of ketone bodies; ketoacidosis De novo synthesis of fatty acids (Palmitic acid)
The biological significance of cholesterol and conversion of cholesterol into bile acids, steroid hormone and vitamin D
Disorders of lipid metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.
Amino acid metabolism
General reactions of amino acid metabolism: Transamination, deamination & decarboxylation, urea cycle and its disorders
Catabolism of phenylalanine and tyrosine and their metabolic disorders (Phenylketonuria, Albinism, alkaptonuria, tyrosinemia)
Synthesis and significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline, adrenaline
Catabolism of heme; hyperbilirubinemia and jaundice
UNIT IV Nucleic acid metabolism and genetic information transfer
Biosynthesis of purine and pyrimidine nucleotides
Catabolism of purine nucleotides and Hyperuricemia and Gout disease
Organization of mammalian genome
Structure of DNA and RNA and their functions DNA replication (semi-conservative model)
Transcription of RNA synthesis Genetic code,
Translation or protein synthesis and inhibitors
UNIT V Enzymes
Introduction, properties, nomenclature and IUB classification of enzymes Enzyme kinetics (Michaelis plot, Line Weaver Burke plot)
Enzyme inhibitors with examples
Regulation of enzymes: enzyme induction and repression, allosteric enzymes regulation
Therapeutic and diagnostic applications of enzymes and isoenzymes
Coenzymes –Structure and biochemical functions
Recommended Books (Latest Editions)
1. Principles of Biochemistry by Lehninger.
2. Harper’s Biochemistry by Robert K. Murry, Daryl K. Granner and Victor W. Rodwell.
3. Biochemistry by Stryer.
4. Biochemistry by D. Satyanarayan and U.Chakrapani
5. Textbook of Biochemistry by Rama Rao.
6. Textbook of Biochemistry by Deb.
7. Outlines of Biochemistry by Conn and Stumpf
8. Practical Biochemistry by R.C. Gupta and S. Bhargavan.
9. Introduction of Practical Biochemistry by David T. Plummer. (3rd Edition)
10. Practical Biochemistry for Medical students by Rajagopal and Ramakrishna.
11. Practical Biochemistry by Harold Varley.
First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
First Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
Suggested readings:
