Pharmaceutical Organic Chemistry III Theory
UNIT-I
Stereo isomerism
Optical isomerism –
Optical activity, enantiomerism, diastereoisomerism, meso compounds
Elements of symmetry, chiral and achiral molecules
DL system of nomenclature of optical isomers, sequence rules, RS system of
nomenclature of optical isomers
Reactions of chiral molecules
Racemic modification and resolution of racemic mixture.
Asymmetric synthesis: partial and absolute
UNIT-II
Geometrical isomerism
Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)
Methods of determination of the configuration of geometrical isomers.
Conformational isomerism in Ethane, n-Butane and Cyclohexane.
Stereoisomerism in biphenyl compounds (Atropisomerism) and conditions for optical
activity.
Stereospecific and stereoselective reactions
UNIT-III
Heterocyclic compounds:
Nomenclature and classification
Synthesis, reactions and medicinal uses of the following compounds/derivatives
Pyrrole, Furan, and Thiophene
Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene
UNIT-IV
Synthesis, reactions and medicinal uses of the following compounds/derivatives
Pyrazole, Imidazole, Oxazole and Thiazole.
Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine
Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives
UNIT-V
Reactions of synthetic importance
Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch
reduction, Wolff Kishner reduction.
Oppenauer-oxidation and Dakin reaction.
Beckmann’s rearrangement and Schmidt rearrangement.
Claisen-Schmidt condensation
Recommended Books (Latest Editions)
- Organic chemistry by I.L. Finar, Volume-I & II.
- A text book of organic chemistry – Arun Bahl, B.S. Bahl.
- Heterocyclic Chemistry by Raj K. Bansal
- Organic Chemistry byMorrison and Boyd
- Heterocyclic Chemistry by T.L. Gilchris
Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
