811ET Advanced Instrumentation Techniques Notes, Books, Syllabus

UNIT I

Nuclear Magnetic Resonance spectroscopy
Introduction,
Principles of H-NMR and C-NMR,
Chemical shift, factors affecting chemical shift, coupling constant, Spin – spin coupling, relaxation, instrumentation and applications

Mass Spectrometry
Principles, Fragmentation, Ionization techniques – Electron impact, chemical ionization, MALDI, FAB, Analyzers-Time of flight and Quadrupole, instrumentation, applications

UNIT II

Thermal Methods of Analysis: Principles, instrumentation and applications of

Thermogravimetric Analysis (TGA),
Differential Thermal Analysis (DTA),
Differential Scanning Calorimetry (DSC)

X-Ray Diffraction Methods:
Origin of X-rays, basic aspects of crystals, Xray Crystallography, rotating crystal technique, single-crystal diffraction, powder diffraction, structural elucidation and applications.

UNIT III

Calibration and validation-as per ICH and USFDA guidelines
Calibration of following Instruments
Electronic balance,
UV-Visible spectrophotometer,
IR spectrophotometer,
Fluorimeter,
Flame Photometer,
HPLC and GC

UNIT IV

Radio immune assay: Importance, various components, Principle, different methods, Limitation and Applications of Radioimmunoassay

Extraction techniques: General principle and procedure involved in the solid-phase extraction and liquid-liquid extraction

UNIT V

Hyphenated techniques-LC-MS/MS, GC-MS/MS, HPTLC-MS.

Recommended Books (Latest Editions)

Instrumental Methods of Chemical Analysis by B.K Sharma
Organic spectroscopy by Y.R Sharma
Text book of Pharmaceutical Analysis by Kenneth A. Connors
Vogel’s Text book of Quantitative Chemical Analysis by A.I. Vogel
Practical Pharmaceutical Chemistry by A.H. Beckett and J.B. Stenlake
Organic Chemistry by I. L. Finar
Organic spectroscopy byWilliam Kemp
Quantitative Analysis of Drugs by D. C. Garrett
Quantitative Analysis of Drugs in Pharmaceutical Formulations by P. D. Sethi
Spectrophotometric identification of Organic Compounds by Silverstein

Final Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

Final Year B Pharm Sem VII	BP701T Instrumental Methods of Analysis Theory
BP702T Industrial Pharmacy Theory	BP703T Pharmacy Practice Theory
BP704T Novel Drug Delivery System Theory	BP705 P Instrumental Methods of Analysis Practical

Final Year B Pharm Sem VII	BP801T Biostatistics and Research Methodology Theory
BP802T Social and Preventive Pharmacy Theory	BP803ET Pharmaceutical Marketing Theory
BP804ET Pharmaceutical Regulatory Science Theory	BP805ET Pharmacovigilance Theory
BP806ET Quality Control and Standardization of Herbals Theory	BP807ET Computer-Aided Drug Design Theory
BP808ET Cell and Molecular Biology Theory	BP809ET Cosmetic Science Theory
BP810ET Experimental Pharmacology Theory	BP811ET Advanced Instrumentation Techniques Theory
BP812ET Dietary supplements and Nutraceuticals	Pharmaceutical Product Development

811ET Advanced Instrumentation Techniques Notes, Books, Syllabus