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811ET Advanced Instrumentation Techniques Notes, Books, Syllabus

UNIT I

Nuclear Magnetic Resonance spectroscopy
Principles of H-NMR and C-NMR, chemical shift, factors affecting chemical shift, coupling constant, Spin – spin coupling, relaxation, instrumentation and applications
Mass Spectrometry- Principles, Fragmentation, Ionization techniques – Electron impact, chemical ionization, MALDI, FAB, Analyzers-Time of flight and Quadrupole, instrumentation, applications

UNIT II

Thermal Methods of Analysis: Principles, instrumentation and applications of

Thermogravimetric Analysis (TGA),
Differential Thermal Analysis (DTA),
Differential Scanning Calorimetry (DSC)

X-Ray Diffraction Methods:
Origin of X-rays, basic aspects of crystals, Xray Crystallography, rotating crystal technique, single-crystal diffraction, powder diffraction, structural elucidation and applications.

UNIT III

Calibration and validation-as per ICH and USFDA guidelines
Calibration of following Instruments
Electronic balance,
UV-Visible spectrophotometer,
IR spectrophotometer,
Fluorimeter,
Flame Photometer,
HPLC and GC

UNIT IV

Radio immune assay: Importance, various components, Principle, different methods, Limitation and Applications of Radioimmunoassay

Extraction techniques: General principle and procedure involved in the solid-phase extraction and liquid-liquid extraction

UNIT V

Hyphenated techniques-LC-MS/MS, GC-MS/MS, HPTLC-MS.

  1. Instrumental Methods of Chemical Analysis by B.K Sharma
  2. Organic spectroscopy by Y.R Sharma
  3. Text book of Pharmaceutical Analysis by Kenneth A. Connors
  4. Vogel’s Text book of Quantitative Chemical Analysis by A.I. Vogel
  5. Practical Pharmaceutical Chemistry by A.H. Beckett and J.B. Stenlake
  6. Organic Chemistry by I. L. Finar
  7. Organic spectroscopy byWilliam Kemp
  8. Quantitative Analysis of Drugs by D. C. Garrett
  9. Quantitative Analysis of Drugs in Pharmaceutical Formulations by P. D. Sethi
  10. Spectrophotometric identification of Organic Compounds by Silverstein

Final Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise

Final Year B Pharm Sem VIIBP701T Instrumental Methods of Analysis Theory
BP702T Industrial Pharmacy TheoryBP703T Pharmacy Practice Theory
BP704T Novel Drug Delivery System TheoryBP705 P Instrumental Methods of Analysis Practical
Final Year B Pharm Sem VIIBP801T Biostatistics and Research Methodology Theory
BP802T Social and Preventive Pharmacy TheoryBP803ET Pharmaceutical Marketing Theory
BP804ET Pharmaceutical Regulatory Science TheoryBP805ET Pharmacovigilance Theory
BP806ET Quality Control and Standardization of Herbals TheoryBP807ET Computer-Aided Drug Design Theory
BP808ET Cell and Molecular Biology TheoryBP809ET Cosmetic Science Theory
BP810ET Experimental Pharmacology TheoryBP811ET Advanced Instrumentation Techniques Theory
BP812ET Dietary supplements and NutraceuticalsPharmaceutical Product Development

Suggested readings

Recommended readings:

  • Roll on deodrant base ingredients

  • Use Aartificial Intelligence for optimisation of pharmaceutical formulation

  • Bayesian approch for optimisation of pharmaceutical formulation