Experimental Pharmacology Theory, Notes, PDF Books, MCQ
Study of CPCSEA and OECD guidelines for maintenance, breeding
and conduct of experiments on laboratory animals, Common lab
animals: Description and applications of different species and strains
of animals. Popular transgenic and mutant animals.
Techniques for collection of blood and common routes of drug
administration in laboratory animals, Techniques of blood collection
Preclinical screening models
a. Introduction: Dose selection, calculation and conversions,
preparation of drug solution/suspensions, a grouping of animals and
importance of sham negative and positive control groups.
The rationale for the selection of animal species and sex for the study.
b. Study of screening animal models for
Diuretics, nootropics, anti-Parkinson’s, antiasthmatics,
Preclinical screening models: for CNS activity- analgesic,
antipyretic, anti-inflammatory, general anaesthetics, sedative and
hypnotics, antipsychotic, antidepressant, antiepileptic, anti parkinsonism, Alzheimer’s disease
Preclinical screening models: for ANS activity, sympathomimetics,
sympatholytics, parasympathomimetics, parasympatholytics, skeletal
muscle relaxants, drugs acting on the eye, local anaesthetics
Preclinical screening models: for CVS activity- antihypertensives,
diuretics, antiarrhythmic, antidyslepidemic, anti aggregatory,
coagulants, and anticoagulants
Preclinical screening models for other important drugs like antiulcer, antidiabetic, anticancer and antiasthmatics.
Research methodology and Bio-statistics
Selection of research topic, review of literature, research hypothesis and study design
Pre-clinical data analysis and interpretation using Students ‘t’ test
and one-way ANOVA. Graphical representation of data
Recommended Books (latest edition):
- Fundamentals of experimental Pharmacology-byM.N.Ghosh
- Hand book of Experimental Pharmacology-S.K.Kulakarni
- CPCSEA guidelines for laboratory animal facility.
- Drug discovery and Evaluation by Vogel H.G.
- Drug Screening Methods by Suresh Kumar Gupta and S. K. Gupta
- Introduction to biostatistics and research methods by PSS Sundar Rao and J Richard
Final Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise