Table of contents
Pharmacology I Theory
UNIT-I General Pharmacology
a. Introduction to Pharmacology- Definition, historical landmarks and scope of pharmacology, nature and source of drugs, essential drugs concept and routes of drug administration, Agonists, antagonists( competitive and non-competitive), spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy.
b. Pharmacokinetics- Membrane transport, absorption, distribution, metabolism and excretion of drugs .Enzyme induction, enzyme inhibition, kinetics of elimination
UNIT-II General Pharmacology
a. Pharmacodynamics- Principles and mechanisms of drug action. Receptor theories and classification of receptors, regulation of receptors. drug receptors interactions signal transduction mechanisms, G-protein–coupled receptors, ion channel receptors, transmembrane enzyme-linked receptors, transmembrane JAK-STAT binding receptor and receptors that regulate transcription factors, dose-response relationship, therapeutic index, combined effects of drugs and factors modifying drug action.
b. Adverse drug reactions.
c. Drug interactions (pharmacokinetic and pharmacodynamic)
d. Drug discovery and clinical evaluation of new drugs –Drug discovery phase, preclinical evaluation phase, clinical trial phase, phases of clinical trials and pharmacovigilance.
UNIT-III Pharmacology of drugs acting on peripheral nervous system
a. Organization and function of ANS.
b.Neurohumoral transmission,co-transmission and classification of neurotransmitters.
c. Parasympathomimetics, Parasympatholytics, Sympathomimetics, sympatholytics.
d. Neuromuscular blocking agents and skeletal muscle relaxants (peripheral).
e. Local anaesthetic agents.
f. Drugs used in myasthenia gravis and glaucoma
UNIT-IV Pharmacology of drugs acting on central nervous system
a. Neurohumoral transmission in the C.N.S.special emphasis on the importance of various
neurotransmitters like GABA, Glutamate, Glycine, serotonin, and dopamine.
b. General anaesthetics and pre-anaesthetics.
c. Sedatives, hypnotics and centrally acting muscle relaxants.
d. Anti-epileptics
e. Alcohols and disulfiram
UNIT-V Pharmacology of drugs acting on central nervous system
a. Psychopharmacological agents: Antipsychotics, antidepressants, anti-anxiety agents,
anti-manics and hallucinogens.
b. Drugs used in Parkinson’s disease and Alzheimer’s disease.
c. CNS stimulants and nootropics.
d. Opioid analgesics and antagonists
e. Drug addiction, drug abuse, tolerance and dependence.
Second Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise
