May 20, 2024

Cold Cream Pharmaceutics Lab Practical Manual PDF

Cold Cream Pharmaceutics Lab Practical

Aim: To Prepare, Evaluate and Submit Cold Cream

Requirements:

Chemicals: Bees Wax, Liquid Paraffin, Borax, Methyl Paraben, Propyl Paraben, Perfume.

Apparatus: Beaker, Measuring Cylinder, Evaporating Dish, Water Bath.

Theory:
Cold cream is water in oil type of emulsion. It produced cooling sensation by the slow evaporation of water present in the cream, after application of cream to the skin. It should possess emollient action and the layer left on the skin after application should be non occlusive.

  • Procedure:

1) Accurately weigh all the ingredients.

2) Melt Bees wax, Liquid Paraffin and Propyl Paraben in order of increasing melting point in evaporating dish.

3) Dissolve Methyl Paraben, Borax in Water at 75⁰ C on water bath.

4) Filter it if required.

5) Then add above solution in to the previously melted mixture with continuous stirring and form homogeneous mixture.

6) Remove from water bath and cool to room temperature with continuous stirring.

7) Add Perfun to the preparation at room temperature.

8) Transfer in to a suitable container, cork it, label and then submit.

  • Category: Emollient
  • Dose: As this product contains no medicament it may be used as required.
  • Storage: It should be stored in tightly closed and completely filled containers. It is usually dispensed in jars of glass or plastic material.
  • Precautions:

○ If hypersensitivity to any of the components stop the use of cold cream.

○ To avoid contamination during use do not allow the open mouth of container to come in contact with any surface.

O Keep away from children.

Definitions:

○ Emollient: Emollients are moisturizing treatments applied directly to the skin to soothe and hydrate it. They cover the skin with a protective film to trap in moisture. Emollients are often used to help manage dry, itchy or scaly skin conditions such as eczema, psoriasis and ichthyosis.

Emulsifying agents: Emulsifying agent are the third substance or agent which produce the film at the interface between two immiscible liquids and stabilized the system, those agents are called emulsifying agent or emulsifier or emulgent.

Vehicle: Vehicles or solvents are the medium in which ingredients of a formulation are dissolved, suspended or dispersed.

Preservative: The chemical substances used in various pharmaceutical dosage forms and cosmetic preparations to prevent or inhibit microbial growth.

Organoleptic Agent: These are the agents encompass a range of additives responsible for colouring, flavouring, sweetening texturing formulations.


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