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Cetrimide cream Pharmaceutics Lab

To Prepare, Evaluate and Submit Cetrimide Cream

  • Requirements:
  • Theory: Cetrimide or alkyl-trimethyl ammonium bromide is an antiseptic which is a mixture of three quaternary, ammonium compounds: tetradonium bromide, cetrimonium bromide and laurtrimonium bromide. It is a creamy white, voluminous, free-flowing powder, a faint odour and has a bitter test. It is freely soluble in water but soluble in warm water and practically insoluble in solvent ether. It is used as a bactericide and astringent. Cetostearyl alcohol and liquid paraffin are used as emulsifying agents in this formulation. Purified water is act as a vehicle.

Formula:

  1. Weight all the ingredients in the required quantity.
  2. Dissolve cetostearyl alcohol in the liquid paraffin with the help of heat in one beaker(Oily Phase)
  3. In another beaker at the same temperature dissolve cetrimide in purified water (Aqueous Phase).
  4. Add first beaker preparation (Oily Phase) in warm condition to second beaker preparation(Aqueous Phase)
  5. Stir the mixture until it cool.
  6. Transfer in a suitable container and then label.
  • Storage: preserve in a well-closed container.
  • Direction: For external use only
  • Definition:

Antiseptic: An antiseptic is an antimicrobial substance or compound that is applied to living tissue/skin to reduce the possibility of infection, sepsis or putrefaction.

Bactericide: A bactericide or bacteriocide is an agent or drug which kills the bacteria.

Emulsifying agent: Emulsifying agents are the third substance or agent which produce the film at the interface between two immiscible liquids and stabilized the system, those agents are called emulsifying agent or emulsifier or emulgent.

Vehicle: Vehicles or solvents are the medium in which ingredients of a formulation are dissolved, suspended or dispersed.

Suggested readings: