Ex Pharm software (Experimental – Pharmacology) - Series
Unit 1
a. Computers in Pharmaceutical Research and Development: A General Overview: History of Computers in
Pharmaceutical Research and Development. Statistical modeling in Pharmaceutical research and development: Descriptive versus Mechanistic Modeling, Statistical Parameters, Estimation, Confidence Regions, Nonlinearity at the Optimum, Sensitivity Analysis, Optimal Design, Population Modeling
b. Quality-by-Design In Pharmaceutical Development: Introduction, ICH Q8 guideline, Regulatory and industry views on QbD, Scientifically based QbD – examples of application
Unit 2
Computational Modeling of Drug Disposition: Podcast link
Introduction, Modeling Techniques: Drug Absorption, Solubility, Intestinal Permeation, Drug Distribution ,Drug Excretion, Active Transport; P-gp, BCRP, Nucleoside Transporters, hPEPT1, ASBT, OCT, OATP, BBB-Choline Transporter.
Unit 3
Computer-aided formulation development: Concept of optimization, Optimization parameters, Factorial design, Optimization technology & Screening design. Computers in Pharmaceutical Formulation: Development of pharmaceutical emulsions, microemulsion drug carriers Legal Protection of Innovative Uses of Computers in R&D, The Ethics of Computing in Pharmaceutical Research, Computers in Market analysis
Unit 4
a. Computer-aided biopharmaceutical characterization: Gastrointestinal absorption simulation. Introduction, Theoretical background, Model construction, Parameter sensitivity analysis, Virtual trial, Fed vs. fasted state, In vitro dissolution and in vitroin vivo correlation, Biowaiver considerations
b. Computer Simulations in Pharmacokinetics and Pharmacodynamics: Introduction, Computer Simulation: Whole
Organism, Isolated Tissues, Organs, Cell, Proteins and Genes. c. Computers in Clinical Development: Clinical Data Collection and Management, Regulation of Computer Systems
Unit 5
Artificial Intelligence (AI),
Robotics and
Computational fluid dynamics: General overview,
Pharmaceutical Automation,
Pharmaceutical applications,
Advantages and Disadvantages.
Current Challenges and Future Directions.
Suggested readings:
D. Pharmacy Syllabus PCI, Subjects list, PDF, Books, MCQ, Notes
B. Pharmacy Syllabus PCI, Subjects list, PDF, Books, MCQ, Notes
Pharm D. Syllabus PCI, Subjects list, PDF, Books, MCQ, Notes
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