Unit 1
Targeted Drug Delivery Systems: Concepts, Events and biological process involved in drug targeting. Tumor targeting and Brain specific delivery
Unit 2
Targeting Methods: introduction preparation and evaluation. Nano Particles & Liposomes: Types, preparation and evaluation.
Unit 3
Micro Capsules / Micro Spheres: Types, preparation and evaluation , Monoclonal Antibodies ; preparation and application, preparation and application of Niosomes, Aquasomes, Phytosomes, Electrosomes.
Unit 4
Pulmonary Drug Delivery Systems : Aerosols, propellents, ContainersTypes, preparation and evaluation, Intra Nasal Route Delivery systems; Types, preparation and evaluation.
Unit 5
Nucleic acid based therapeutic delivery system : Gene therapy, introduction (ex-vivo & in-vivo gene therapy). Potential target diseases for gene therapy (inherited disorder and cancer). Gene expression systems (viral and nonviral gene transfer). Liposomal gene delivery systems. Biodistribution and Pharmacokinetics. knowledge of therapeutic antisense molecules and aptamers as drugs of future.
REFERENCES
- Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded,Marcel Dekker, Inc., New York, 1992.
- S.P.Vyas and R.K.Khar, Controlled Drug Delivery – concepts and advances, VallabhPrakashan, New Delhi, First edition 2002.
- N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, NewDelhi, First edition 1997 (reprint in 2001).
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