Tetracycline Capsules 250 mg Pharmaceutics Lab Practical Manual PDF
Aim: To Prepare, Evaluate and Submit 250 mg Tetracycline Capsules
- Chemicals: Tetracycline HCL, Dried Starch, Dried Talcum
• Apparatus: Mortar and Pestle, Capsule Shell, Sieve, Hand Operated Capsule Filling Machine
Capsules are solid dosage forms in which drug or mixture of drug is enclosed in water soluble shell. A capsule shell is made up of Gelatin. Capsules usually contain a single dose of active ingredients and are intended for oral administration. Tetracycline is a yellow, odourless, crystalline powder. Tetracycline is stable in air but exposure to strong sunlight causes it to darken. Tetracycline is very slightly soluble in water, freely soluble in alkali hydroxide solutions, sparingly soluble in alcohol and practically insoluble in chloroform and in ether.In this formulation tetracycline hydrochloride is used as an antibiotic to treat a wide range of infections. Dried starch as a bulking agent and talcum as glidant.
1) Accurately weigh all the ingredients.
2) Pass the dried starch and talcum powder through sieve number 100.
3) Mix all the ingredients with ascending order by their weights in mortar and pestle to form uniform blend.
4) Select an empty capsule shell of size “0” and fill the content in capsule shell using hand operated capsule filling machine.
5) Store the capsules in air-tight container.
Storage: Store in air-tight container in cool and dry place.
Precaution: Take after meal. Take with caution in gastric ulcer or hyperacidity.
Antibiotics: A medicine or agents that inhibit the growth of or destroys microorganism.
Bulking agents: Bulking agents are also called as fillers or diluents. These agents are used to fill the bulk of formulation. Fillers are often used in tablets or capsules because the amount of active drug is too small to be handled conveniently.
Glidants: Glidants are the substances which are used to improve flow properties of powder, granules or formulation.