Terpin Hydrate Linctus IP 66 Pharmaceutics Lab PCI Syllabus

Formula:

IngredientsQuantity given Quantity taken Activity
Terpin Hydrate50gExpectorant 
Orange oil0.2 mlFlavouring agent
Glycerine400mlHumectant
Alcohol425 mlCo-solvent
Syrup100 mlSweetener
Purified Waterq.s 1000 mlVehicle

Procedure:

Terpin Hydrate was dissolved in a mixture of alcohol and glycerin.

orange oil syrup was added and volume made up with purified water.

The elixir was passed through a muslin cloth to obtain a clear solution.

Category :

expectorant

Dose:

4ml (Reduce the thickness or viscosity of bronchial secretions thus increasing mucus flow that can be removed more easily through coughing.)

Use:

Terpin hydrate is an expectorant

About Terpin Hydrate :

Terpin hydrate is an expectorant commonly used to loosen mucus in patients presenting with acute or chronic bronchitis, and related conditions. Terpin is derived from oil of turpentine, oregano, thyme and eucalyptus. In 1855 Lepin who first investigated terpin reported that it acted upon the mucous membranes and also the nervous system in a manner similar to the oil of turpentine. Terpin hydrate was available in the USA in 1907 in the preparations such as Elixir of Terpin Hydrate alone or in combination with codein or heroin as an antitussives. It was banned by the U.S. Food and Drug Administration (FDA) in the 1990s due to lack of proof of efficacy but is a medicine available in a number of countries worldwide commonly used in combination with codein. At present it is FDA approved for as an OTC use in combination formulations (with acetaminophen and other drugs) used as internal analgesics. Terpin was recently introduced as a natural topical insect repellent.

Structure:

Systematic name:

P-MENTHANE-1,8-DIOL MONOHYDRATE

Used in the treatment of acute and chronic bronchitis, pneumonia, bronchiectasis, chronic obstructive pulmonary disease, and infectious and inflammatory diseases of the upper respiratory tract.

It is typically formulated with an antitussive (e.g., codeine) as a combined preparation.

Mechanism of action:

A humectant and expectorant, terpin hydrate works directly on the bronchial secretory cells in the lower respiratory tract to liquify and facilitate the elimination of bronchial secretions.

It also exerts a weak antiseptic effect on the pulmonary parenchyma

Preparations:

  • Elixir of terpin hydrate
  • Elixir of terpin hydrate with codeine
  • Elixir of terpin hydrate with heroin

Reference:

https://drugs.ncats.io/drug/S3V868548T

https://en.wikipedia.org/wiki/Terpin

What is a category of terpin hydrate linctus?

Category of terpin hydrate linctus is expectorant

What is a dose of terpin hydrate linctus?

4ml (Reduce the thickness or viscosity of bronchial secretions thus increasing mucus flow that can be removed more easily through coughing.)

What is mechanism of action of terpin hydrate?

A humectant and expectorant, terpin hydrate works directly on the bronchial secretory cells in the lower respiratory tract to liquify and facilitate the elimination of bronchial secretions.
It also exerts a weak antiseptic effect on the pulmonary parenchyma

How to prepare terpin hydrate linctus?

Terpin Hydrate was dissolved in a mixture of alcohol and glycerin.
orange oil syrup was added and volume made up with purified water.
The elixir was passed through a muslin cloth to obtain a clear solution.

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