Synthesis of Sulphanilamide
BP607P Medicinal Chemistry III Practical : I Preparation of drugs Sulphanilamide * 7-Hydroxy, 4-methyl coumarin * Chlorobutanol * Triphenyl imidazole * Tolbutamide * Hexamine II Assay of drugs Isonicotinic acid hydrazide * Chloroquine * Metronidazole * Dapsone * Chlorpheniramine maleate * Benzyl penicillin III Microwave irradiation technique Synthesis of Phenytoin by Microwave * Synthesis of Aspirin by Microwave IV Drawing structures and reactions using chem draw®
Aim: Synthesis of Sulphanilamide
To synthesis and submit sulphanilamide from p-acetamido benzene sulphanilamide and calculate its percentage yield.
Principle:
Sulphanilamide can be prepared by the reaction of P-acetamido benzene sulphanilamide with Hydrochloric acid or ammonium carbonate. The acetamido groups are easily undergo acid catalysed hydrolysis reaction to form p-amino benzene sulphonamide.
Reaction:
Chemical Required:
Resorcinol – 1.2 g
Ethyl acetoacetate – 2.4 ml
Conc. Sulphuric acid – 7.5 ml
Procedure:
1.5 gm of 4- acetamido benzene sulphonamide is treated with a mixture of 1 ml of conc. Sulphuric acid diluted with 2 ml water. This mixture is gently heated under reflux for 1 hour. Then 3ml of water is added and the solution is boiled again, with the addition of a small quantity of activated charcoal. The solution is filtered while hot, and the filtrate is neutralised with powdered sodium carbonate with stirring until all effervescence ceases and the sulphanilamide is precipitated as a white powder. The solution is cooled,
and filtered, and the sulphanilamide wash with water and dried. Finally, crude sulphanilamide is recrystallized from hot water, to get colourless crystals.
Melting Point: 163 C
Category: Bacteriostatic agent
Report:
The Sulphanilamide was synthesised and submitted, Reported the following
- Theoretical Yield =
- Practical Yield =
- Percentage Yield =
Third Year B Pharm Notes, Syllabus, Books, PDF Subjectwise/Topicwise